Golik A, Averbukh Z, Cohn M, Maor J, Berman S, Shaked U, Modai D
Department of Medicine A, Assaf Harofeh Medical Center, Sackler School of Medicine, Tel Aviv, Israel.
Eur J Clin Pharmacol. 1990;38(4):359-61. doi: 10.1007/BF00315575.
The urinary zinc/creatinine ratio has been measured in five groups of patients with essential hypertension and in a group of healthy controls. The first four groups of patients consisted of subjects being treated for at least three months with captopril alone, hydrochlorothiazide alone, captopril plus hydrochlorothiazide, or captopril and furosemide. The fifth group comprised hypertensive patients not on any medication. The first four patient groups exhibited significantly increased urinary zinc/creatinine ratios when compared to the control and untreated hypertensive groups, but in the two combination regimens there was little zincuria. It is suggested that both diuretics inactivate the zincuric effect of captopril by binding to its sulphydryl group within the tubular lumen.
已对五组原发性高血压患者和一组健康对照者测量了尿锌/肌酐比值。前四组患者分别为仅接受卡托普利治疗至少三个月、仅接受氢氯噻嗪治疗至少三个月、接受卡托普利加氢氯噻嗪治疗、接受卡托普利和呋塞米治疗的受试者。第五组包括未服用任何药物的高血压患者。与对照组和未治疗的高血压组相比，前四组患者的尿锌/肌酐比值显著升高，但在两种联合治疗方案中，锌尿症较少。提示两种利尿剂均通过与肾小管腔内的巯基结合而使卡托普利的促锌尿作用失活。
