Golik A, Modai D, Weissgarten J, Cohen N, Averbukh Z, Sigler E, Zaidenstein R, Shaked U
Clin Pharmacol Ther. 1987 Jul;42(1):42-4. doi: 10.1038/clpt.1987.105.
Serum zinc levels and urinary zinc excretion were compared in 15 patients with essential hypertension taking chronically a combination of hydrochlorothiazide and amiloride as monotherapy, eight patients maintained with hydrochlorothiazide alone, and eight control subjects. Serum zinc values were statistically comparable in all three groups. However, urinary zinc excretion was abnormally elevated in the two patient groups. In the dosage used, amiloride did not have a zinc-sparing effect.
对15例长期服用氢氯噻嗪和阿米洛利联合制剂作为单一疗法的原发性高血压患者、8例仅用氢氯噻嗪维持治疗的患者以及8名对照者的血清锌水平和尿锌排泄情况进行了比较。三组的血清锌值在统计学上具有可比性。然而，两个患者组的尿锌排泄均异常升高。在所使用的剂量下，阿米洛利没有保锌作用。
