Wester P O
Acta Med Scand. 1980;208(3):209-12. doi: 10.1111/j.0954-6820.1980.tb01179.x.
Urinary zinc excretion was studied in a randomized trial in 9 patients during treatment with bendroflumethiazide, chlorthalidone and hydrochlorothiazide and in another 9 patients during treatment with bumetanide, furosemide and triamterene. During treatment with the thiazides, the zinc concentration rose by 30% and the total amount of zinc excretion increased by 60%. In contrast, during treatment with the loop-diuretics, urine zinc concentration diminished and the total amount of zinc excretion increased much less than during therapy with the thiazides. With respect to the importance of zinc as an essential element in human metabolism and the frequency of diuretic treatment, the observed increased urinary losses of zinc deserve further attention.
在一项随机试验中，对9例使用苄氟噻嗪、氯噻酮和氢氯噻嗪治疗的患者以及另外9例使用布美他尼、呋塞米和氨苯蝶啶治疗的患者的尿锌排泄情况进行了研究。在使用噻嗪类利尿剂治疗期间，锌浓度升高了30%，锌排泄总量增加了60%。相比之下，在使用袢利尿剂治疗期间，尿锌浓度降低，锌排泄总量的增加远低于噻嗪类利尿剂治疗期间。鉴于锌作为人体新陈代谢必需元素的重要性以及利尿剂治疗的频率，观察到的尿锌排泄增加值得进一步关注。
