Zumkley H, Bertram H P, Vetter H, Zidek W, Losse H
Horm Metab Res. 1985 May;17(5):256-8. doi: 10.1055/s-2007-1013508.
In 14 hypertensives the effect of captopril (angiotensin-converting enzyme inhibitor) treatment on red blood cell Na+, K+, Mg2+ and Zn2+ concentrations and on plasma Zn2+ concentrations were studied. Intraerythrocytic Zn2+ concentrations increased slightly, whereas plasma zinc concentrations decreased. The concurrence of hypozincemia with side effects resembling the symptoms of zinc deficiency such as loss of smell and taste suggests a role of alterations in zinc metabolism for the pharmacodynamics of captopril.
在14名高血压患者中，研究了卡托普利（血管紧张素转换酶抑制剂）治疗对红细胞钠、钾、镁和锌离子浓度以及血浆锌离子浓度的影响。红细胞内锌离子浓度略有增加，而血浆锌浓度降低。低锌血症与类似锌缺乏症状（如嗅觉和味觉丧失）的副作用同时出现，提示锌代谢改变在卡托普利药效学中起作用。
