Lassoued K, Brenard R, Degos F, Courvalin J C, Andre C, Danon F, Brouet J C, Zine-el-Abidine Y, Degott C, Zafrani S
Laboratoire d'Immunochimie et d'Immunopathologie (INSERM), Hôpital Saint-Louis, Paris, France.
Gastroenterology. 1990 Jul;99(1):181-6. doi: 10.1016/0016-5085(90)91246-3.
Antinuclear antibodies giving a perinuclear fluorescence and directed to a 200-kilodalton polypeptide of the nuclear envelope have been described in primary biliary cirrhosis. The purpose of this study, based on a series of 150 patients with primary biliary cirrhosis, was to ascertain the prevalence of these antibodies and to compare patients with and without these antibodies. Antinuclear antibodies giving a perinuclear fluorescence were demonstrated in 43 of the 150 patients (29%); antibodies directed to the 200-kilodalton polypeptide of the nuclear envelope were found in 40 of these 43 patients. Asthenia, arthralgia, associated extrahepatic diseases, Raynaud's phenomenon, and other antinuclear specificities were significantly less common, and titers of antimitochondrial antibodies were significantly lower in patients with antibodies directed to the 200-kilodalton polypeptide of the nuclear envelope than in patients without these antibodies. Clinical outcome, liver tests, and histological lesions did not significantly differ in patients with and without these antibodies.
在原发性胆汁性肝硬化中已描述了呈现核周荧光且针对核膜200千道尔顿多肽的抗核抗体。本研究基于150例原发性胆汁性肝硬化患者，目的是确定这些抗体的患病率，并比较有和没有这些抗体的患者。150例患者中有43例（29%）检测到呈现核周荧光的抗核抗体；在这43例患者中有40例发现了针对核膜200千道尔顿多肽的抗体。与没有针对核膜200千道尔顿多肽抗体的患者相比，有该抗体的患者乏力、关节痛、相关肝外疾病、雷诺现象及其他抗核特异性显著少见，且抗线粒体抗体滴度显著更低。有和没有这些抗体的患者在临床结局、肝功能检查及组织学病变方面无显著差异。
