在原发性胆汁性肝硬化中被人类自身抗体识别的210-kD核包膜多肽是核孔的主要糖蛋白。
The 210-kD nuclear envelope polypeptide recognized by human autoantibodies in primary biliary cirrhosis is the major glycoprotein of the nuclear pore.
作者信息
Courvalin J C, Lassoued K, Bartnik E, Blobel G, Wozniak R W
机构信息
Centre de Génétique Moléculaire, Centre National de la Recherche Scientifique, Gif sur Yvette, France.
出版信息
J Clin Invest. 1990 Jul;86(1):279-85. doi: 10.1172/JCI114696.
Abstract
We have recently reported a new family of nuclear autoantibodies in a subset of patients with primary biliary cirrhosis. These antibodies bind to a nuclear envelope polypeptide(s) of approximately 200 kD, the exact identity of which was not established. In this study, we show that all of these autoantibodies are directed against a 210-kD integral membrane glycoprotein of the nuclear pore.
摘要
我们最近报道了在一部分原发性胆汁性肝硬化患者中发现的一个新的核自身抗体家族。这些抗体与一种分子量约为200kD的核包膜多肽结合，但其确切身份尚未确定。在本研究中，我们表明所有这些自身抗体均针对核孔的一种210-kD整合膜糖蛋白。
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