马尾松皮提取物对 HeLa 细胞黏附和迁移能力的影响。

Effects of Pinus massoniana bark extract on the adhesion and migration capabilities of HeLa cells.

机构信息

Department of Regenerative Medicine, Tongji University School of Medicine, Shanghai 200092, China.

出版信息

Fitoterapia. 2011 Dec;82(8):1202-5. doi: 10.1016/j.fitote.2011.08.008. Epub 2011 Aug 23.

DOI:10.1016/j.fitote.2011.08.008

Abstract

Pinus massoniana Lamb is a Chinese red pine species used in traditional medicine for the treatment of a variety of human health disorders. Recent studies have shown that P. massoniana bark extract (PMBE) has an anti-proliferation effect on cancer cells. However, it is not clear if PMBE affects cancer cell migration and/or invasion. We tested the effect of PMBE, which has B-type procyanidin as its main constituent, on the adhesion and migration capabilities of HeLa cells, a human cervical cancer cell line, cultured in vitro. Our results showed that PMBE has no significant effect on the adhesion capability of HeLa cells, but strongly inhibits their migration. This finding suggests that PMBE could be a potential therapeutic agent for metastatic cancer.

摘要

马尾松是一种中国的红松物种，在传统医学中用于治疗多种人类健康紊乱。最近的研究表明，马尾松树皮提取物（PMBE）对癌细胞的增殖具有抑制作用。然而，目前尚不清楚 PMBE 是否会影响癌细胞的迁移和/或侵袭。我们测试了 PMBE（其主要成分为 B 型原花青素）对体外培养的人宫颈癌细胞系 HeLa 细胞黏附和迁移能力的影响。结果表明，PMBE 对 HeLa 细胞的黏附能力没有显著影响，但强烈抑制其迁移。这一发现表明 PMBE 可能是一种治疗转移性癌症的潜在治疗剂。