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抗原吸附的磷酸钙纳米颗粒刺激鱼类罗非鱼的先天和适应性免疫反应。

Antigen adsorbed calcium phosphate nanoparticles stimulate both innate and adaptive immune response in fish, Labeo rohita H.

机构信息

Fish Health Management Division, Central Institute of Freshwater Aquaculture, Kausalyaganga, Bhubaneswar, Orissa, India.

出版信息

Cell Immunol. 2011;271(2):350-9. doi: 10.1016/j.cellimm.2011.07.015. Epub 2011 Aug 10.

DOI:10.1016/j.cellimm.2011.07.015
PMID:21889128
Abstract

Calcium phosphate nanoparticles as an antigen/protein delivery was explored in a fish model Labeo rohita H. S-layer protein (of Aeromonas hydrophila) adsorbed on nano sized calcium phosphate particles elicited both innate and adaptive immune parameters which persisted up to 63 days of post immunization through parenteral immunization and gave cross protections.

摘要

将纳米磷酸钙作为抗原/蛋白递送来进行研究，在罗非鱼模型中，纳米磷酸钙颗粒上吸附的嗜水气单胞菌的表面层蛋白（Aeromonas hydrophila）能够引发先天和适应性免疫反应，这种免疫反应持续时间长达 63 天，通过注射免疫的方式产生，并且具有交叉保护作用。

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