National Allergy Research Centre, Department of Dermato-Allergology, Copenhagen University Hospital Gentofte, DK-2900 Hellerup, Denmark.
Sci Total Environ. 2011 Oct 15;409(22):4663-6. doi: 10.1016/j.scitotenv.2011.07.056. Epub 2011 Sep 1.
Nickel and cobalt allergy remain frequent in dermatitis patients. It is important to determine possible nickel and cobalt exposures at work as these may offer important information to regulators and physicians who perform patch testing. Clinical relevance of metal exposure is usually assessed by the treating physician via the medical history and by presentation of allergic contact dermatitis.
To screen unused non-powered hand-held work tools for nickel and cobalt release by using colorimetric spot tests.
MATERIALS & METHODS: A random selection of 200 non-powered hand-held work tools for sale in 2 retailers of home improvement and construction products were analyzed qualitatively for metal release using the colorimetric nickel and cobalt spot tests.
Nickel release was identified from 5% of 200 work tools using the dimethylglyoxime (DMG) test. In 8 of 10, positive results were located to the metal ring that acts like a cuff and is located at the end of the grip. The positive DMG test results were not related to specific categories of work tools. The cobalt spot test gave no positive test reactions.
It appears that the proportion of work tools that release nickel, in amounts that may result in allergic nickel dermatitis, has decreased markedly, when results were compared with a Swedish study performed more than a decade ago. No cobalt release was detected but it should be underscored that hard-metal tools were not examined. Other sources of cobalt may explain the relatively high levels of cobalt allergy in dermatitis patients.
镍和钴过敏在皮炎患者中仍然很常见。确定工作中可能的镍和钴暴露非常重要,因为这可能为进行斑贴试验的监管机构和医生提供重要信息。金属暴露的临床相关性通常由治疗医生通过病史和过敏性接触性皮炎的表现来评估。
使用比色点测试筛选未使用的非动力手持式工作工具是否释放镍和钴。
对 2 家家装和建筑产品零售商销售的 200 件非动力手持式工作工具进行随机选择,使用比色镍和钴点测试对其金属释放进行定性分析。
使用二甲基乙二醛(DMG)测试从 200 件工作工具中的 5%中鉴定出镍释放。在 10 件中的 8 件中,阳性结果位于类似于袖口并位于握把末端的金属环上。阳性 DMG 测试结果与特定类别的工作工具无关。钴点测试未产生阳性测试反应。
与十多年前在瑞典进行的研究相比,释放可能导致过敏性镍皮炎的镍的工作工具的比例似乎明显下降。未检测到钴释放,但应强调的是,未检查硬质合金工具。其他钴源可能解释了皮炎患者中相对较高的钴过敏水平。