Departamento de Informática y Automática, University of Salamanca, Salamanca, Spain.
Immunobiology. 2011 Nov;216(11):1212-27. doi: 10.1016/j.imbio.2011.08.004. Epub 2011 Aug 16.
The study of infectious disease concerns the interaction between the host species and a pathogen organism. The analysis of such complex systems is improving with the evolution of high-throughput technologies and advanced computational resources. This article reviews integrative, systems-oriented approaches to understanding mechanisms underlying infection, immune response and inflammation to find biomarkers of disease and design new drugs. We focus on the systems biology process, especially the data gathering and analysis techniques rather than the experimental technologies or latest computational resources.
传染病研究关注宿主物种与病原体之间的相互作用。随着高通量技术和先进计算资源的发展，对这类复杂系统的分析也在不断改进。本文综述了用于理解感染、免疫反应和炎症机制的综合、面向系统的方法，以寻找疾病的生物标志物并设计新的药物。我们重点介绍了系统生物学方法，特别是数据收集和分析技术，而不是实验技术或最新的计算资源。
