Department of Preclinical and Clinical Pharmacology, University of Florence, viale Pieraccini 6, 50139 Firenze, Italy.
Trends Microbiol. 2011 Oct;19(10):509-15. doi: 10.1016/j.tim.2011.07.007. Epub 2011 Aug 24.
Modelling the networks sustaining the fruitful coexistence between fungi and their mammalian hosts is becoming increasingly important to control emerging fungal pathogens. In a 'systems biology' perspective, the microbiota and host should be seen as an ecosystem, and disease considered as an alteration of the equilibrium. This review addresses host-fungus interaction with a special focus on systems biology approaches to investigate the mechanisms developed by Candida albicans and Aspergillus fumigatus to circumvent host immune responses during fungal infections. Such genome-wide integrative approaches hold the promise to significantly improve our ability to understand which fungal traits can be considered potential threats and the regulatory networks involved in immune subversion.
为了控制新发真菌病原体，对维持真菌与其哺乳动物宿主之间有益共生的网络进行建模正变得越来越重要。从“系统生物学”的角度来看，微生物组和宿主应被视为一个生态系统，而疾病则被视为平衡的改变。本综述主要关注宿主-真菌相互作用，探讨了系统生物学方法在研究白念珠菌和烟曲霉在真菌感染过程中规避宿主免疫反应的机制中的应用。这种全基因组综合方法有望显著提高我们理解哪些真菌特征可被视为潜在威胁以及涉及免疫抑制的调控网络的能力。
