Department of Anesthesiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.
J Arthroplasty. 2012 Apr;27(4):514-9. doi: 10.1016/j.arth.2011.06.027. Epub 2011 Sep 3.
The coexistence of diabetes, hypertension, obesity, and dyslipidemia is defined as metabolic syndrome. Studies show substantial cardiovascular risks among these patients. The risk of patients with metabolic syndrome undergoing total joint arthroplasty (TJA) is unknown. Patients with and without metabolic syndrome undergoing TJA during a 3-year period were analyzed for postoperative complications. Metabolic syndrome was defined by having 3 of the following 4 criteria: obesity (body mass index ≥30 kg/m(2)), dyslipidemia, hypertension, and diabetes. Patients with metabolic syndrome had a significantly higher risk of cardiovascular complications compared with controls (P = .017). The risk of an adverse event increased by 29% and 32%, respectively, when there were 3 or 4 syndrome components. Patients with metabolic syndrome undergoing TJA have increased risk for cardiovascular complications. Our results show that metabolic syndrome may have a clustering effect and pose increased risk when individual risks factors are combined.
糖尿病、高血压、肥胖症和血脂异常同时存在被定义为代谢综合征。研究表明，这些患者存在大量心血管风险。代谢综合征患者行全关节置换术（TJA）的风险尚不清楚。对在 3 年内接受 TJA 的有和无代谢综合征的患者进行术后并发症分析。代谢综合征的定义是符合以下 4 项标准中的 3 项：肥胖症（体重指数≥30kg/m2）、血脂异常、高血压和糖尿病。与对照组相比，代谢综合征患者发生心血管并发症的风险显著更高（P=0.017）。当存在 3 个或 4 个综合征成分时，不良事件的风险分别增加了 29%和 32%。行 TJA 的代谢综合征患者有增加的心血管并发症风险。我们的结果表明，代谢综合征可能存在聚类效应，当单独的风险因素结合在一起时，会增加风险。
