Margetts B M
MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, U.K.
Klin Wochenschr. 1990;68 Suppl 20:11-5.
The answer to the question the title of this paper puts is: No a P/S ratio diet alone does not lower blood pressure! Although a number of cross-sectional and other studies do suggest that there is a relationship between P/S ratio and blood pressure it is not possible in these studies to eliminate the potentially confounding effects of other aspects of diet and lifestyle which are also either different or affected by the experiment. Most of the evidence from properly controlled randomised experimental studies do not provide support for an effect of an elevation of the dietary P/S ratio alone on blood pressure. These experiments have been conducted at various levels of total fat intake, across a range of blood pressures (but not very high blood pressures) and for both a short or longer duration. The levels of polyunsaturated fats have also varied from modest increases to quite substantial increases. It is therefore unlikely that aspects of sample selection, range of dietary change or length of observation can account for the failure of these studies to show an effect on blood pressure. From other observational and experimental studies it is apparent that dietary change can affect blood pressure. It may be that combinations of dietary factors need to occur in synchrony to affect blood pressure. It is therefore possible that a high P/S ratio diet in combination with for example potassium, calcium or magnesium or other dietary factors may influence blood pressure.(ABSTRACT TRUNCATED AT 250 WORDS)
不,单纯的多不饱和/饱和脂肪酸比值饮食并不能降低血压!尽管一些横断面研究和其他研究确实表明多不饱和/饱和脂肪酸比值与血压之间存在关联,但在这些研究中,无法消除饮食和生活方式其他方面潜在的混杂效应,这些方面要么不同,要么受实验影响。来自恰当控制的随机实验研究的大多数证据并不支持单纯提高饮食中多不饱和/饱和脂肪酸比值对血压有影响这一观点。这些实验在不同的总脂肪摄入量水平、一系列血压范围(但不是非常高的血压)下进行,且持续时间有短有长。多不饱和脂肪的水平也从适度增加到大幅增加不等。因此,样本选择、饮食变化范围或观察时长等方面不太可能解释这些研究未能显示出对血压有影响的原因。从其他观察性和实验性研究来看,饮食变化显然会影响血压。可能饮食因素的组合需要同时出现才能影响血压。因此,例如高多不饱和/饱和脂肪酸比值饮食与钾、钙或镁或其他饮食因素相结合,可能会影响血压。(摘要截选至250字)