Child Development and Exercise Center, Wilhelmina Children's Hospital, University Medical Center Utrecht, Room KB2.056.0, PO Box 85090, 3508 AB Utrecht, The Netherlands.
Rheumatology (Oxford). 2011 Nov;50(11):2113-24. doi: 10.1093/rheumatology/ker292. Epub 2011 Sep 2.
Idiopathic inflammatory myopathies (IIMs) are a group of rare heterogeneous autoimmune skeletal muscle disorders characterized by muscle weakness, excessive muscle fatigue and diminished aerobic fitness. Exercise training could be one way to prevent or delay the negative effects of the disease and the impairments seen in patients with an IIM. The objective was to examine whether exercise training is safe and effective in patients with an IIM.
All experimental studies that assessed the safety and/or efficacy of an exercise training programme in patients with an IIM except for case studies were reviewed. Pre-MEDLINE, MEDLINE and EMBASE database searching was done up to November 2010. Information was extracted on the number of participants, characteristics of participants, type of intervention, type of outcome measure, type of study design, report characteristics, geographical origin and risk of bias within studies. The change (percentage and significance) in group mean or median for each outcome measure in each study was determined as well.
Two randomized controlled trials, one non-randomized controlled trial and nine uncontrolled trials were included. No studies in children were found. Safety measures did not worsen and efficacy measures improved or did not change. Most of the included studies had a high selection and/or allocation bias.
In conclusion, it appears that exercise training is safe and effective in adult patients with active as well as inactive stable IIMs. However, more studies with a well-controlled design are needed. In addition, studies in children with an IIM are indicated.
特发性炎性肌病（IIM）是一组罕见的异质性自身免疫性骨骼肌疾病，其特征为肌肉无力、过度肌肉疲劳和有氧健身能力下降。运动训练可能是预防或延缓疾病的负面影响以及 IIM 患者出现的损害的一种方法。目的是检查运动训练在 IIM 患者中是否安全有效。
除病例研究外，我们对评估 IIM 患者运动训练计划安全性和/或疗效的所有实验研究进行了回顾。在预MEDLINE、MEDLINE 和 EMBASE 数据库中进行了截至 2010 年 11 月的检索。我们提取了参与者人数、参与者特征、干预类型、结果测量类型、研究设计类型、报告特征、地理起源和研究内偏倚风险等信息。还确定了每个研究中每个结果测量的组平均值或中位数的变化（百分比和显著性）。
纳入了两项随机对照试验、一项非随机对照试验和九项非对照试验。未发现儿童研究。安全性措施没有恶化，疗效措施改善或没有变化。大多数纳入的研究存在高选择和/或分配偏倚。
总之，运动训练似乎对活动期和非活动稳定期的成人 IIM 患者是安全有效的。但是，需要更多设计良好的对照研究。此外，表明有必要对 IIM 儿童进行研究。
