Canfield L M, Corrigan J J, Plezia P M, Jeter M, Sayers S, Alberts D S
Department of Biochemistry, University of Arizona, Tucson 85724.
Nutr Cancer. 1990;13(4):263-9. doi: 10.1080/01635589009514068.
Plasma vitamin K concentrations and prothrombin coagulation activity were determined in 26 normal adults who had received daily beta-carotene supplementation (0, 15, 30, or 60 mg) for six months. Neither plasma vitamin K nor coagulation activity were significantly decreased at any supplementation level. Thus, chronic beta-carotene supplementation, even at high daily doses, is not expected to result in clinical vitamin K deficiency. The data suggest separate mechanisms for intestinal absorption of beta-carotene and vitamin K.
对26名正常成年人进行了血浆维生素K浓度和凝血酶原凝血活性的测定，这些成年人每日补充β-胡萝卜素（0、15、30或60毫克），持续六个月。在任何补充水平下，血浆维生素K和凝血活性均未显著降低。因此，即使每日高剂量长期补充β-胡萝卜素，预计也不会导致临床维生素K缺乏。数据表明，β-胡萝卜素和维生素K在肠道吸收的机制不同。
