Mokhtari Amirmajdi Monireh, Mokhtari Amirmajdi Nemat Allah, Eftekharzadeh Mashhadi Iman, Jabari Azad Farahzad, Tavakol Afshari Jalil, Shakeri Mohammad-Taghi
Department of Medical Mycoparasitology, Mashhad University of Medical Sciences, Mashhad, Iran.
Iran J Allergy Asthma Immunol. 2011 Sep;10(3):221-6.
Inhalation of fungal spores is shown to participate in the development of allergic rhinitis symptoms. In this study, relation between presence of Alternaria in the human nasal cavity and allergic rhinitis is assessed. In a case-control study, 58 allergic rhinitis patients were compared with a well-matched control group of fifty healthy volunteers for sensitization to Alternaria (by skin prick test) and detection of Alternaria in their nasal mucous by conventional methods (microscopy with Methylene Blue stain and culture in Sabourad dextrose agar). Severity of the disease was determined according to the ARIA classification. Pearson chi-square test was applied to compare the proportional difference between the study groups for detection of Alternaria in the nasal cavity, and sensitization to Alternaria. Relation between detection of Alternaria and allergic rhinitis was significant [OR = 18.18 (4.02-82.50)] In addition, sensitization to Alternaria showed a significant relation with the disease [OR = 2.8 (2.1-3.8)]. There was a significant relation between the presence of Alternaria in the nasal cavity and sensitization to Alternaria [OR = 10.4 (3.8-28.3)]. Both sensitization to Alternaria and presence of Alternaria in the nasal cavity did not have a significant relation with the severity of allergic rhinitis. This study suggests Alternaria as a major allergen that its presence in the nasal cavity and subsequent development of sensitization have significant role in the induction of allergic rhinitis.
吸入真菌孢子被证明参与过敏性鼻炎症状的发展。在本研究中，评估了人类鼻腔中链格孢菌的存在与过敏性鼻炎之间的关系。在一项病例对照研究中，将58名过敏性鼻炎患者与50名健康志愿者组成的匹配良好的对照组进行比较，以检测对链格孢菌的致敏情况（通过皮肤点刺试验），并通过传统方法（亚甲蓝染色显微镜检查和在沙氏葡萄糖琼脂培养基上培养）检测其鼻腔黏液中的链格孢菌。根据ARIA分类确定疾病的严重程度。应用Pearson卡方检验比较研究组之间鼻腔中链格孢菌检测和对链格孢菌致敏的比例差异。链格孢菌检测与过敏性鼻炎之间的关系具有显著性[比值比（OR）=18.18（4.02 - 82.50）]。此外，对链格孢菌的致敏与疾病之间存在显著关系[OR = 2.8（2.1 - 3.8）]。鼻腔中链格孢菌的存在与对链格孢菌的致敏之间存在显著关系[OR = 10.4（3.8 - 28.3）]。对链格孢菌的致敏和鼻腔中链格孢菌的存在与过敏性鼻炎的严重程度均无显著关系。本研究表明链格孢菌是一种主要过敏原，其在鼻腔中的存在以及随后致敏的发展在过敏性鼻炎的诱发中具有重要作用。
