一种针对基质金属蛋白酶 2 的简单灵敏检测而定制的氧化石墨烯-肽荧光传感器。
A graphene oxide-peptide fluorescence sensor tailor-made for simple and sensitive detection of matrix metalloproteinase 2.
机构信息
Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
出版信息
Chem Commun (Camb). 2011 Oct 14;47(38):10680-2. doi: 10.1039/c1cc13975d. Epub 2011 Sep 2.
PMID:21892449
Abstract
A graphene oxide-peptide based fluorescence sensor has been developed for matrix metalloproteinase 2 (MMP2), and its applicability has been demonstrated by monitoring the concentration of MMP2 secreted by HeLa cells, revealing that HeLa cells with a density of 5.48 × 10(5) cells per mL can produce 22 nM in cell culture media in 24 h.
摘要
一种基于氧化石墨烯-肽的荧光传感器已被开发用于基质金属蛋白酶 2（MMP2），并通过监测 HeLa 细胞分泌的 MMP2 的浓度来证明其适用性，结果表明，细胞密度为 5.48×10(5)个/mL 的 HeLa 细胞在 24 小时内可以在细胞培养基中产生 22 nM 的 MMP2。
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