Vieira F G K, Di Pietro P F, Boaventura B C B, Ambrosi C, Rockenbach G, Fausto Ma A, Crippa C G, Da Silva E L
Post-Graduate Program in Nutrition, Santa Catarina Federal Universiy, Florianopolis, SC, Brazil.
Nutr Hosp. 2011 May-Jun;26(3):528-36. doi: 10.1590/S0212-16112011000300015.
To assess the association between physiological, physical, lifestyle and nutritional variables and oxidative stress biomarkers in women with breast cancer.
This cross-sectional study was conducted on 55 women newly diagnosed with breast cancer. The extent of oxidative stress was analyzed by the measurement of plasma lipid hydroperoxides (LH), thiobarbituric acid reactive substances (TBARS), protein carbonyl, whole blood reduced glutathione (GSH) and serum antioxidant capacity (AC). Diet data were obtained from food frequency questionnaire. Linear regression was used to determine the association between the variables studied and oxidative stress biomarkers. The protein carbonyl data was not included in the linear regression analyses since the data did not show a normal distribution, even after logarithmic and other transformations.
After adjusting for energy intake, the intake of chicken and high-fat dairy products was associated with increased levels of LH, while vitamin E intake was associated with decreased LH levels (R² = 23.8%). Intake of oils was associated with increased levels of TBARS (R² = 6.82%). Positive axillary lymph node status was associated with decreased levels of GSH (R² = 9.31%). Increasing age was directly associated with levels of AC, while animal fat, dairy product, and sweet food intakes were associated with low levels of AC (R² = 41.42%).
Intake of chicken, vitamin E, dairy products (particularly high-fat dairy products), oils, animal fat, and sweet foods, along with axillary lymph node status and age, may be important determinants of oxidative stress in women with breast cancer.
评估生理、身体、生活方式和营养变量与乳腺癌女性氧化应激生物标志物之间的关联。
对55名新诊断为乳腺癌的女性进行了这项横断面研究。通过测量血浆脂质过氧化物（LH）、硫代巴比妥酸反应性物质（TBARS）、蛋白质羰基、全血还原型谷胱甘肽（GSH）和血清抗氧化能力（AC）来分析氧化应激程度。饮食数据通过食物频率问卷获得。采用线性回归来确定所研究变量与氧化应激生物标志物之间的关联。蛋白质羰基数据未纳入线性回归分析，因为即使经过对数和其他转换后，该数据仍未呈现正态分布。
在调整能量摄入后，鸡肉和高脂乳制品的摄入量与LH水平升高相关，而维生素E摄入量与LH水平降低相关（R² = 23.8%）。油类摄入量与TBARS水平升高相关（R² = 6.82%）。腋窝淋巴结阳性状态与GSH水平降低相关（R² = 9.31%）。年龄增长与AC水平直接相关，而动物脂肪、乳制品和甜食的摄入量与AC水平较低相关（R² = 41.42%）。
鸡肉、维生素E、乳制品（特别是高脂乳制品）、油类、动物脂肪和甜食的摄入量，以及腋窝淋巴结状态和年龄，可能是乳腺癌女性氧化应激的重要决定因素。
