Sithithaworn Paiboon, Andrews Ross H, Nguyen Van De, Wongsaroj Thitima, Sinuon Muth, Odermatt Peter, Nawa Yukifumi, Liang Song, Brindley Paul J, Sripa Banchob
Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Parasitol Int. 2012 Mar;61(1):10-6. doi: 10.1016/j.parint.2011.08.014. Epub 2011 Aug 25.
This review highlights the current status and control of liver fluke infections in the Mekong Basin countries where Opisthorchis and Clonorchis are highly endemic. Updated data on prevalence and distribution have been summarized from presentations in the "96 Years of Opisthorchiasis. International Congress of Liver Flukes". It is disturbing that despite treatment and control programs have been in place for decades, all countries of the Lower Mekong Basin are still highly endemic with O. viverrini and/or C. sinensis as well as alarmingly high levels of CCA incidence. A common pattern that is emerging in each country is the difference in transmission of O. viverrini between lowlands which have high prevalence versus highlands which have low prevalence. This seems to be associated with wetlands, flooding patterns and human movement and settlement. A more concerted effort from all community, educational, public health and government sectors is necessary to successfully combat this fatal liver disease of the poor.
本综述重点介绍了湄公河流域国家肝吸虫感染的现状及防控情况，这些国家华支睾吸虫和肝片形吸虫高度流行。“华支睾吸虫病96年。国际肝吸虫大会”上的报告总结了关于流行率和分布的最新数据。令人不安的是，尽管治疗和控制项目已经实施了数十年，但湄公河下游流域所有国家华支睾吸虫和/或中华分支睾吸虫仍然高度流行，且胆管癌发病率高得惊人。每个国家都出现了一种共同模式，即华支睾吸虫在低地（流行率高）和高地（流行率低）之间传播存在差异。这似乎与湿地、洪水模式以及人类流动和定居有关。所有社区、教育、公共卫生和政府部门需要更加齐心协力，才能成功对抗这种穷人的致命肝病。
