Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, NCI, Rockville, MD 20852, USA.
Cancer Prev Res (Phila). 2011 Sep;4(9):1353-5. doi: 10.1158/1940-6207.CAPR-11-0360.
In this issue of the journal, Michaud and colleagues report a 48% increased risk of meningioma in obese individuals compared with individuals with a normal body mass index (BMI). This large prospective cohort study adds weight to the suggested link between BMI and meningioma, thus contributing to the growing number of cancer sites likely associated with body fatness. Although the exact mechanisms underlying the BMI-meningioma link are unclear, possible mediators include hormonal factors, immunologic response, and levels of insulin or insulin-like growth factors, each of which has been implicated by various levels of evidence in meningioma risk. Understanding the relationships between body fatness, height, and hormonal and immunologic factors could provide important clues to the etiology of meningioma and may have implications for the early detection and prevention of these tumors.
在本期杂志中，Michaud 及其同事报告称，肥胖个体患脑膜瘤的风险比体重正常的个体高 48%。这项大型前瞻性队列研究为 BMI 与脑膜瘤之间的关联提供了更多证据，因此有助于增加与体脂肪相关的癌症部位数量。尽管 BMI 与脑膜瘤关联的确切机制尚不清楚，但可能的中介因素包括激素因素、免疫反应以及胰岛素或胰岛素样生长因子水平，这些因素都在脑膜瘤风险中得到了不同程度的证据支持。了解体脂肪、身高以及激素和免疫因素之间的关系，可以为脑膜瘤的病因提供重要线索，并可能对这些肿瘤的早期发现和预防具有重要意义。
