RG Neuroimaging, Max Planck Institute of Psychiatry, Kraepelinstrasse 2-10, 80804 Munich, Germany.
Philos Trans A Math Phys Eng Sci. 2011 Oct 13;369(1952):3708-29. doi: 10.1098/rsta.2011.0078.
This paper reviews the existing body of knowledge on the neural correlates of spontaneous oscillations, functional connectivity and brain plasticity in human non-rapid eye movement (NREM) sleep. The first section reviews the evidence that specific sleep events as slow waves and spindles are associated with transient increases in regional brain activity. The second section describes the changes in functional connectivity during NREM sleep, with a particular focus on changes within a low-frequency, large-scale functional brain network. The third section will discuss the possibility that spontaneous oscillations and differential functional connectivity are related to brain plasticity and systems consolidation, with a particular focus on motor skill acquisition. Implications for the mode of information processing per sleep stage and future experimental studies are discussed.
本文综述了人类非快速眼动（NREM）睡眠中自发性脑活动震荡、功能连接和脑可塑性的神经关联的现有知识体系。第一部分回顾了特定睡眠事件（如慢波和纺锤波）与局部脑活动短暂增加相关的证据。第二部分描述了 NREM 睡眠期间功能连接的变化，特别关注低频、大规模功能脑网络内的变化。第三部分将讨论自发性脑活动震荡和功能连接的差异是否与脑可塑性和系统巩固有关，特别关注运动技能习得。讨论了各睡眠阶段信息处理模式的意义和未来的实验研究。
