School of Physics, University of Sydney, Sydney, NSW 2006, Australia.
Philos Trans A Math Phys Eng Sci. 2011 Oct 13;369(1952):3840-54. doi: 10.1098/rsta.2011.0120.
Arousal is largely controlled by the ascending arousal system of the hypothalamus and brainstem, which projects to the corticothalamic system responsible for electroencephalographic (EEG) signatures of sleep. Quantitative physiologically based modelling of brainstem dynamics theory is described here, using realistic parameters, and links to EEG are outlined. Verification against a wide range of experimental data is described, including arousal dynamics under normal conditions, sleep deprivation, stimuli, stimulants and jetlag, plus key features of wake and sleep EEGs.
觉醒主要由下丘脑和脑干的上行觉醒系统控制，该系统投射到皮质丘脑系统，负责睡眠的脑电图 (EEG) 特征。本文描述了使用现实参数的脑干动力学理论的定量生理基础建模，并概述了与 EEG 的联系。描述了对广泛的实验数据的验证，包括正常条件下的觉醒动力学、睡眠剥夺、刺激、兴奋剂和时差反应，以及清醒和睡眠 EEG 的关键特征。
