通过双重空间位阻提高单 DNA 功能化金纳米粒子的产率。
Improving the yield of mono-DNA-functionalized gold nanoparticles through dual steric hindrance.
机构信息
Key Laboratory of Standardization and Measurement for Nanotechnology, National Center for Nanoscience and Technology, No. 11 Zhongguancun Beiyitiao, Beijing 100190, PR China.
出版信息
J Am Chem Soc. 2011 Oct 5;133(39):15284-7. doi: 10.1021/ja205712a. Epub 2011 Sep 12.
A novel strategy of dual steric hindrance, which was obtained by Janus modification of gold nanoparticles (Au NPs) and volume exclusion of DNA, was adopted to prepare mono-DNA-modified Au NPs. The yield of mono-DNA-functionalized Au NPs significantly improved from 44 to 70% in the reaction between Au NPs and thiolated DNA. Furthermore, the specificity of mono-DNA-functionalized Au NPs was enhanced from 57 to 95%. The as-prepared Au NPs without postsynthetic treatment showed good controllability in self-assembly fabrication of complex nanostructures.
采用金纳米粒子（Au NPs）的双面位阻修饰和 DNA 的体积排除的新策略，制备了单 DNA 修饰的 Au NPs。Au NPs 与巯基化 DNA 反应时，单 DNA 功能化 Au NPs 的产率从 44%显著提高到 70%。此外，单 DNA 功能化 Au NPs 的特异性从 57%提高到 95%。未经后期合成处理的所制备的 Au NPs 显示出在复杂纳米结构的自组装制造中具有良好的可控性。
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