Department of Dermatology, Seoul National University College of Medicine, and Seoul National University Bundang Hospital, 166 Gumi-10, Seongnam, Gyeonggi 463-707, Korea.
Br J Dermatol. 2012 Jan;166(1):59-66. doi: 10.1111/j.1365-2133.2011.10598.x.
The ultraviolet (UV)-induced red fluorescence of patients with acne has been considered to be caused by Propionibacterium acnes.
To study the correlation of the facial red fluorescence with the casual sebum level and the number of acne lesions and to investigate the difference in clinical features, according to both distribution and proportion of fluorescence.
A total of 878 patients clinically diagnosed with acne vulgaris were included. Inflammatory and noninflammatory acne lesions were counted separately. UV fluorescent photography and casual sebum level measurements were performed. UV-induced fluorescence patterns were classified according to the facial distribution. The proportions of UV-induced red fluorescence were calculated.
We identified six different fluorescence distribution patterns in the T-zone (the forehead, nose and chin) and three different patterns in the U-zone (both cheeks). The proportion of fluorescence in the U-zone showed a positive correlation with the casual sebum level and the number of acne lesions. In the T-zone, the fluorescence proportion correlated with the casual sebum level, but not with the number of acne lesions. As the patients' age and the age at onset increased, the distribution of fluorescence changed from the upper part of the T-zone to the lower part, and to the centre of the face in the U-zone.
Our results support the hypothesis that the origin of facial red fluorescence is sebum. In patients with acne, analyses of the pattern and proportion of UV-induced red fluorescence can be useful for evaluating the sebum secretion and selecting efficient treatment modalities.
人们认为痤疮患者的紫外线（UV）诱导的红色荧光是由痤疮丙酸杆菌引起的。
研究面部红色荧光与皮脂随机水平和痤疮病变数量的相关性，并根据荧光的分布和比例，研究临床特征的差异。
共纳入 878 例临床诊断为寻常痤疮的患者。分别计数炎性和非炎性痤疮病变。进行 UV 荧光摄影和皮脂随机水平测量。根据面部分布对 UV 诱导的荧光模式进行分类。计算 UV 诱导的红色荧光的比例。
我们在 T 区（额头、鼻子和下巴）中确定了六种不同的荧光分布模式，在 U 区（双颊）中确定了三种不同的模式。U 区的荧光比例与皮脂随机水平和痤疮病变数量呈正相关。在 T 区，荧光比例与皮脂随机水平相关，但与痤疮病变数量无关。随着患者年龄和发病年龄的增加，荧光的分布从 T 区的上部变为下部，再变为 U 区的面部中央。
我们的结果支持这样一种假设，即面部红色荧光的来源是皮脂。在痤疮患者中，对 UV 诱导的红色荧光的模式和比例进行分析有助于评估皮脂分泌，并选择有效的治疗方式。
