Department of Dermatology and Venereology, Medical University, Plovdiv, Bulgaria.
Photodermatol Photoimmunol Photomed. 2010 Dec;26(6):285-9. doi: 10.1111/j.1600-0781.2010.00541.x.
Orange-red fluorescence in the follicle openings, induced by ultraviolet A light, originates from porphyrins, the metabolic products of Propionibacteria acnes.
To investigate the relationship of orange-red follicular fluorescence with the severity of acne and the amount of sebum secretion.
Twenty-five volunteers were included. The severity of acne was rated on a 4-point scale. The casual sebum level was measured using a Sebumeter and the follicular fluorescence was determined using the camera Visiopor.
Casual sebum level and the intensity of fluorescence (percentage of the area and number of orange-red spots) were higher at the T zone than at the U zone in all patients regardless of their skin type. Sebum amount and area of fluorescence spots were significantly negative in correlation with the clinical grade of acne. There was a significant positive correlation between the orange-red fluorescence and the casual sebum level.
The orange-red fluorescence showed stronger correlation with the presence of non-inflammatory acne lesions (comedones) and high sebum amount than the presence of inflammatory acne lesions (pustules) and low sebum amount. The fluorescence diagnostic imaging could be useful in the objective evaluation and monitoring of treatment efficacy in subjects with acne-prone skin and patients with acne.
毛囊口处由痤疮丙酸杆菌代谢产物卟啉引起的紫外线 A 光诱导的橙红色荧光。
探讨痤疮严重程度和皮脂分泌量与毛囊橙红色荧光之间的关系。
共纳入 25 名志愿者。痤疮严重程度采用 4 分制评分。使用皮脂计测量皮脂水平，使用 Visiopor 相机测定毛囊荧光强度。
无论皮肤类型如何，所有患者的 T 区皮脂量和荧光强度（面积百分比和橙红色斑点数量）均高于 U 区。皮脂量和荧光斑点面积与痤疮的临床分级呈显著负相关。橙红色荧光与皮脂水平呈显著正相关。
与炎症性痤疮皮损（脓疱）和低皮脂量相比，橙红色荧光与非炎症性痤疮皮损（粉刺）和高皮脂量的相关性更强。荧光诊断成像可用于痤疮易发皮肤和痤疮患者的客观评估和疗效监测。
