通过在台湾癌症患者样本中提出的诊断标准来检查癌症相关性疲劳。
An examination of cancer-related fatigue through proposed diagnostic criteria in a sample of cancer patients in Taiwan.
机构信息
Department of Family Medicine, Cardinal Tien Hospital, Xindian District, New Taipei City, 231 Taiwan.
出版信息
BMC Cancer. 2011 Sep 6;11:387. doi: 10.1186/1471-2407-11-387.
BACKGROUND
Fatigue among cancer patients has often been reported in the literature; however, great variations have been documented, ranging from 15% to 90%, probably due to the lack of a widely accepted definition and established diagnostic criteria for cancer-related fatigue. The objective of this study was to evaluate the proposed International Statistical Classification of Diseases and Related Health Problems (10th revision) (ICD-10) criteria in a sample of cancer patients from a medical center and a regional teaching hospital in northern Taiwan. More accurate prevalence estimates of CRF may result in improved diagnoses and management of one of the most common symptoms associated with cancer and its treatment.
METHODS
Since self-reporting from patients is the most effective and efficient method to measure fatigue, the ICD-10 criteria for fatigue were used. The ICD-10 criteria questionnaire was translated into Chinese and was approved by experts. Patients were recruited from outpatient palliative and oncology clinics and from palliative and oncology inpatient units.
RESULTS
Of the 265 cancer patients that were interviewed between 21 October 2008 and 28 October 2009, 228 (86%) reported having at least 2 weeks of fatigue in the past month, and further evaluation with the ICD-10 criteria showed that 132 (49.8%) had cancer-related fatigue. Internal consistency was very good, which was indicated by a Cronbach alpha of 0.843.
CONCLUSION
The prevalence of diagnosable CRF in the patients in this sample, of whom most were under palliative treatment, was 49.8%, which was probably somewhat lower than in some of the previous reports that have used less-strict criteria. In addition, among the various criteria of the proposed diagnostic criteria, the most frequently reported symptoms in our sample populations were regarding sleep disturbance and physical factors. Although they will require further replication in other samples, these formal diagnostic criteria can serve as a step toward a common language and a better understanding of the severity range of CRF.
背景
癌症患者的疲劳在文献中经常被报道；然而，由于缺乏广泛接受的定义和既定的癌症相关疲劳诊断标准，所记录的变化范围从 15%到 90%不等。本研究的目的是评估国际疾病分类第十版（ICD-10）标准在台湾北部一家医学中心和一家地区教学医院的癌症患者样本中的适用性。更准确的 CRF 患病率估计可能会改善与癌症及其治疗相关的最常见症状之一的诊断和管理。
方法
由于患者的自我报告是衡量疲劳最有效和最有效的方法，因此使用了 ICD-10 疲劳标准。ICD-10 标准问卷被翻译成中文，并经过专家认可。患者从姑息治疗和肿瘤门诊以及姑息治疗和肿瘤住院病房招募。
结果
在 2008 年 10 月 21 日至 2009 年 10 月 28 日期间接受采访的 265 名癌症患者中，有 228 名（86%）报告在过去一个月中有至少 2 周的疲劳，进一步使用 ICD-10 标准评估显示，有 132 名（49.8%）患有癌症相关疲劳。内部一致性非常好，Cronbach alpha 为 0.843。
结论
在这个样本中，接受姑息治疗的患者中可诊断的 CRF 患病率为 49.8%，可能略低于以前使用不太严格标准的一些报告。此外，在提出的诊断标准的各种标准中，我们的样本人群中报告最多的症状是睡眠障碍和身体因素。尽管它们需要在其他样本中进一步复制，但这些正式的诊断标准可以作为一种共同语言和更好地理解 CRF 严重程度范围的一步。
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