Department of Otorhinolaryngology, Academic Medical Centre, Amsterdam, The Netherlands.
Fam Pract. 2012 Apr;29(2):147-53. doi: 10.1093/fampra/cmr062. Epub 2011 Sep 5.
Despite the evidence demonstrating that antibiotics are of little benefit in acute rhinosinusitis (ARS), GPs continue to prescribe them, possibly in an attempt to prevent potentially dangerous complications. In this study, we present epidemiological data about the incidence, course and severity of such complications in the Netherlands.
This retrospective cohort study included all patients hospitalized in The Netherlands in 2004 with a complication of ARS. Records were made of the symptoms of ARS and the complication, demographics, medical history, medical treatment preceding hospitalization, diagnostic techniques, therapeutic management, course and outcome.
Forty-seven patients with 48 complications (16 intracranial and 32 orbital) were included. In the intracranial group (mean age 35.9 years), six patients had been treated with oral antibiotics prior to hospitalization. While hospitalized, all patients were treated with intravenous antibiotics and 15 underwent surgery. Eight patients recovered fully after treatment, three patients had residual symptoms and three patients died (missing data: 2). Of the 31 patients with orbital complications (mean age 17.4 years), 14 received oral antibiotics before admission. While hospitalized, all patients were treated with intravenous antibiotics and 13 underwent surgery. Twenty-seven patients recovered fully and two had residual symptoms (missing data: 2).
Severe ARS complications occur in an otherwise healthy population in an estimated 1:12,000 paediatric and 1:32,000 adult cases in the Netherlands. Our study suggests that antibiotic treatment of ARS in general practice does not play a role in preventing complications.
尽管有证据表明抗生素在急性鼻-鼻窦炎(ARS)中益处不大,但全科医生仍继续开处方,可能是为了预防潜在的危险并发症。在这项研究中,我们提供了荷兰此类并发症的发病率、病程和严重程度的流行病学数据。
这是一项回顾性队列研究,纳入了 2004 年在荷兰因 ARS 并发症住院的所有患者。记录了 ARS 的症状和并发症、人口统计学、病史、住院前的医疗、诊断技术、治疗管理、病程和结果。
共纳入 47 例患者的 48 例并发症(16 例颅内和 32 例眶内)。在颅内组(平均年龄 35.9 岁)中,有 6 例患者在住院前接受了口服抗生素治疗。住院期间,所有患者均接受了静脉内抗生素治疗,15 例患者接受了手术。8 例患者经治疗后完全康复,3 例患者仍有症状,3 例患者死亡(缺失数据:2)。31 例眶内并发症患者(平均年龄 17.4 岁)中,14 例患者在入院前接受了口服抗生素治疗。住院期间,所有患者均接受了静脉内抗生素治疗,13 例患者接受了手术。27 例患者完全康复,2 例患者仍有症状(缺失数据:2)。
在荷兰,严重的 ARS 并发症在儿童中估计每 12000 例和成人中每 32000 例中发生 1 例,发生在其他健康人群中。我们的研究表明,一般实践中对 ARS 的抗生素治疗并未起到预防并发症的作用。