National Center for Research Resources, National Institutes of Health, Bethesda, MD.
National Center for Research Resources, National Institutes of Health, Bethesda, MD.
Chest. 2011 Sep;140(3):764-767. doi: 10.1378/chest.11-0710.
Recognizing the need to increase the efficiency and quality of translating basic discovery into treatment and prevention strategies for patients and the public, the National Institutes of Health (NIH) announced the Clinical and Translational Science Awards (CTSAs) in 2006. Academic health centers that competed successfully for these awards agreed to work as a consortium and in cooperation with the NIH to improve the translation process by training the next generation of investigators to work in interdisciplinary teams, developing public-private partnerships in the movement of basic discovery to preclinical and clinical studies and trials, improving clinical research management, and engaging with communities to ensure their involvement in shaping research questions and in implementing research results. The CTSAs have addressed the crucial need to improve the quality and efficiency of clinical research by (1) providing training for clinical investigators and for bench researchers to facilitate their participation in the clinical and translational research environment, (2) developing more systematic approaches to clinical research management, and (3) engaging communities as active participants in the design and conduct of clinical research studies and trials and as leaders in implementing health advances that are of high importance to them. We provide an overview of the CTSA activities with attention to these three areas, which are essential to developing efficient clinical research efforts and effective implementation of research results on a national level.
为了提高将基础发现转化为患者和公众的治疗和预防策略的效率和质量，美国国立卫生研究院（NIH）于 2006 年宣布了临床与转化科学奖（CTSAs）。成功竞争这些奖项的学术健康中心同意作为联盟，并与 NIH 合作，通过培训下一代研究人员在跨学科团队中工作、在将基础发现转化为临床前和临床研究和试验的公私伙伴关系方面发展、改善临床研究管理以及与社区合作，确保他们参与制定研究问题和实施研究结果，从而改进转化过程。CTSAs 通过以下方式解决了提高临床研究质量和效率的关键需求：（1）为临床研究人员和基础研究人员提供培训，以促进他们参与临床和转化研究环境；（2）开发更系统的临床研究管理方法；（3）将社区作为积极参与者纳入临床研究设计和实施，并作为实施对他们至关重要的健康进展的领导者。我们概述了 CTSA 的活动，重点关注这三个方面，这对于在国家层面上开展高效的临床研究工作和有效实施研究结果至关重要。
