Philips Research, Eindhoven, The Netherlands.
Cancer Res. 2011 Sep 15;71(18):5955-60. doi: 10.1158/0008-5472.CAN-11-1254. Epub 2011 Sep 6.
From February 7-11, 2011, the multidisciplinary Lorentz Workshop Circulating Tumor Cell (CTC) Isolation and Diagnostics: Toward Routine Clinical Use was held in Leiden (The Netherlands) to discuss progress and define challenges and potential solutions for development of clinically useful circulating tumor cell (CTC) diagnostics. CTCs, captured as "liquid biopsy" from blood, for counting and characterization using pathology and molecular assays, are expected to replace metastatic tissue biopsies to be used to predict drug response and resistance and to monitor therapy response and cancer recurrence. CTCs are highly heterogeneous; therefore, cancer type-specific isolation technologies, as well as complex clinical interpretation software, are required.
2011 年 2 月 7 日至 11 日，荷兰莱顿举行了多学科洛伦兹研讨会循环肿瘤细胞（CTC）的分离和诊断：迈向常规临床应用，旨在讨论进展并确定临床有用的循环肿瘤细胞（CTC）诊断技术的挑战和潜在解决方案。CTC 可作为“液体活检”从血液中捕获，使用病理学和分子检测进行计数和特征分析，有望取代转移性组织活检，用于预测药物反应和耐药性，以及监测治疗反应和癌症复发。CTC 具有高度异质性；因此，需要癌症类型特异性的分离技术以及复杂的临床解释软件。
