• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

研究用七价肉毒杆菌抗毒素给药后 F 型肠型肉毒中毒的初始恢复和反弹。

Initial recovery and rebound of type f intestinal colonization botulism after administration of investigational heptavalent botulinum antitoxin.

机构信息

Division of Foodborne, Waterborne, and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, US Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

出版信息

Clin Infect Dis. 2011 Nov;53(9):e125-8. doi: 10.1093/cid/cir550. Epub 2011 Sep 6.

DOI:10.1093/cid/cir550
PMID:21896700
Abstract

Investigational heptavalent botulinum antitoxin (HBAT) is now the primary antitoxin for US noninfant botulism patients. HBAT consists of equine Fab/F(ab')2 IgG fragments, which are cleared from circulation faster than whole immunoglobulins. Rebound botulism after antitoxin administration is not previously documented but occurred in our patient 10 days after HBAT administration.

摘要

研究用七价肉毒杆菌抗毒素（HBAT）现已成为美国非婴儿肉毒中毒患者的主要抗毒素。HBAT 由马源 Fab/F(ab')2 IgG 片段组成，其在体内的清除速度快于全免疫球蛋白。抗毒素治疗后的肉毒杆菌毒素反弹此前并无记录，但在我们的患者中于 HBAT 治疗后 10 天发生。

相似文献

1
Initial recovery and rebound of type f intestinal colonization botulism after administration of investigational heptavalent botulinum antitoxin.研究用七价肉毒杆菌抗毒素给药后 F 型肠型肉毒中毒的初始恢复和反弹。
Clin Infect Dis. 2011 Nov;53(9):e125-8. doi: 10.1093/cid/cir550. Epub 2011 Sep 6.
2
Investigational heptavalent botulinum antitoxin (HBAT) to replace licensed botulinum antitoxin AB and investigational botulinum antitoxin E.研究用七价肉毒杆菌抗毒素（HBAT）替代许可的肉毒杆菌抗毒素 AB 和研究用肉毒杆菌抗毒素 E。
MMWR Morb Mortal Wkly Rep. 2010 Mar 19;59(10):299.
3
Safety and Improved Clinical Outcomes in Patients Treated With New Equine-Derived Heptavalent Botulinum Antitoxin.新型马源七价肉毒毒素抗毒素治疗患者的安全性和临床结局改善。
Clin Infect Dis. 2017 Dec 27;66(suppl_1):S57-S64. doi: 10.1093/cid/cix816.
4
Workgroup Report by the Joint Task Force Involving American Academy of Allergy, Asthma & Immunology (AAAAI); Food Allergy, Anaphylaxis, Dermatology and Drug Allergy (FADDA) (Adverse Reactions to Foods Committee and Adverse Reactions to Drugs, Biologicals, and Latex Committee); and the Centers for Disease Control and Prevention Botulism Clinical Treatment Guidelines Workgroup-Allergic Reactions to Botulinum Antitoxin: A Systematic Review.联合工作组报告，涉及美国过敏、哮喘和免疫学会（AAAAI）；食物过敏、过敏反应、皮肤病和药物过敏（FADDA）（食物不良反应委员会和药物、生物制品和乳胶不良反应委员会）；以及疾病控制和预防中心肉毒杆菌临床治疗指南工作组-肉毒杆菌抗毒素过敏反应：系统评价。
Clin Infect Dis. 2017 Dec 27;66(suppl_1):S65-S72. doi: 10.1093/cid/cix827.
5
Anti-immunoglobulin responses to IgG, F(ab')2, and Fab botulinum antitoxins in mice.小鼠对IgG、F(ab')2和Fab肉毒抗毒素的抗免疫球蛋白反应。
Immunopharmacol Immunotoxicol. 2003 Aug;25(3):397-408. doi: 10.1081/iph-120024507.
6
Development and evaluation of candidate vaccine and antitoxin against botulinum neurotoxin serotype F.开发和评估针对肉毒梭菌神经毒素血清型 F 的候选疫苗和抗毒素。
Clin Immunol. 2010 Nov;137(2):271-80. doi: 10.1016/j.clim.2010.07.005. Epub 2010 Aug 8.
7
Development and preclinical evaluation of a new F(ab')₂ antitoxin against botulinum neurotoxin serotype A.新型抗 A 型肉毒神经毒素 F(ab')₂ 抗体的研制与临床前评价
Biochimie. 2010 Oct;92(10):1315-20. doi: 10.1016/j.biochi.2010.06.010. Epub 2010 Jun 18.
8
Outbreak of foodborne botulism in Alexandria, Egypt: modulating indications for administration of heptavalent botulinum antitoxin.埃及亚历山大里亚发生食源性肉毒中毒疫情：调整使用七价肉毒杆菌抗毒素的指征。
Environ Sci Pollut Res Int. 2021 Nov;28(43):61547-61553. doi: 10.1007/s11356-021-14909-z. Epub 2021 Jun 28.
9
Foodborne botulism treated with heptavalent botulism antitoxin.经食源性肉毒中毒抗毒素治疗的肉毒中毒。
Ann Pharmacother. 2013 Feb;47(2):e12. doi: 10.1345/aph.1R646. Epub 2013 Jan 29.
10
Experience with the use of an investigational F(ab')2 heptavalent botulism immune globulin of equine origin during an outbreak of type E botulism in Egypt.在埃及E型肉毒中毒暴发期间使用一种研究性马源F(ab')2七价肉毒中毒免疫球蛋白的经验。
Clin Infect Dis. 1996 Aug;23(2):337-40. doi: 10.1093/clinids/23.2.337.

引用本文的文献

1
Cauda equina nerve root enhancement in adult intestinal toxemia botulism.成人肠道型肉毒中毒中的马尾神经根强化
BMC Neurol. 2025 Aug 22;25(1):343. doi: 10.1186/s12883-025-04365-4.
2
Conflicting Clinical Presentation of Infection with and in a 5-Month-Old Infant.一名5个月大婴儿感染[具体病原体1]和[具体病原体2]的矛盾临床表现
J Pediatr Clin Pract. 2025 Jan 23;15:200140. doi: 10.1016/j.jpedcp.2025.200140. eCollection 2025 Mar.
3
Development of Effective Medical Countermeasures Against the Main Biowarfare Agents: The Importance of Antibodies.
针对主要生物战剂的有效医学应对措施的研发：抗体的重要性
Microorganisms. 2024 Dec 18;12(12):2622. doi: 10.3390/microorganisms12122622.
4
Passive Immunisation in the Treatment of Infectious Diseases Related to Highly Potent Bacterial Toxins.被动免疫疗法在治疗与高活性细菌毒素相关的传染病中的应用
Biomedicines. 2024 Dec 23;12(12):2920. doi: 10.3390/biomedicines12122920.
5
Navigating the Complexities Involving the Identification of Botulinum Neurotoxins (BoNTs) and the Taxonomy of BoNT-Producing Clostridia.探索涉及肉毒神经毒素（BoNTs）鉴定和产毒梭菌分类的复杂性。
Toxins (Basel). 2023 Sep 3;15(9):545. doi: 10.3390/toxins15090545.
6
A Three-Monoclonal Antibody Combination Potently Neutralizes BoNT/G Toxin in Mice.三株单克隆抗体联合能有效中和小鼠中的 BoNT/G 毒素。
Toxins (Basel). 2023 Apr 30;15(5):316. doi: 10.3390/toxins15050316.
7
Pathogenicity and virulence of . 的致病性和毒力。
Virulence. 2023 Dec;14(1):2205251. doi: 10.1080/21505594.2023.2205251.
8
A Four-Monoclonal Antibody Combination Potently Neutralizes Multiple Botulinum Neurotoxin Serotypes C and D.一种四克隆抗体组合能有效中和多种 C 和 D 型肉毒神经毒素。
Toxins (Basel). 2021 Sep 10;13(9):641. doi: 10.3390/toxins13090641.
9
The Novel Clostridial Neurotoxin Produced by Strain IBCA10-7060 Is Immunologically Equivalent to BoNT/HA.IBCA10-7060 株产生的新型梭菌神经毒素与 BoNT/HA 具有免疫等价性。
Toxins (Basel). 2019 Dec 20;12(1):9. doi: 10.3390/toxins12010009.
10
Safety and Pharmacokinetics of a Four Monoclonal Antibody Combination Against Botulinum C and D Neurotoxins.一种针对肉毒杆菌C型和D型神经毒素的四种单克隆抗体组合的安全性和药代动力学
Antimicrob Agents Chemother. 2019 Sep 9;63(12). doi: 10.1128/AAC.01270-19. Epub 2019 Oct 7.