研究用七价肉毒杆菌抗毒素给药后 F 型肠型肉毒中毒的初始恢复和反弹。
Initial recovery and rebound of type f intestinal colonization botulism after administration of investigational heptavalent botulinum antitoxin.
机构信息
Division of Foodborne, Waterborne, and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, US Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
出版信息
Clin Infect Dis. 2011 Nov;53(9):e125-8. doi: 10.1093/cid/cir550. Epub 2011 Sep 6.
Investigational heptavalent botulinum antitoxin (HBAT) is now the primary antitoxin for US noninfant botulism patients. HBAT consists of equine Fab/F(ab')2 IgG fragments, which are cleared from circulation faster than whole immunoglobulins. Rebound botulism after antitoxin administration is not previously documented but occurred in our patient 10 days after HBAT administration.
研究用七价肉毒杆菌抗毒素（HBAT）现已成为美国非婴儿肉毒中毒患者的主要抗毒素。HBAT 由马源 Fab/F(ab')2 IgG 片段组成，其在体内的清除速度快于全免疫球蛋白。抗毒素治疗后的肉毒杆菌毒素反弹此前并无记录，但在我们的患者中于 HBAT 治疗后 10 天发生。
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