State Key Laboratory for Infectious Disease Prevention and Control, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Am J Trop Med Hyg. 2011 Sep;85(3):442-5. doi: 10.4269/ajtmh.2011.10-0368.
Tahyna virus (TAHV) is widely distributed in Europe and Asia. A previous study reported a high level of conservation of the TAHV genome in isolates from Europe. During 2006 and 2007, three Tahyna virus isolates from mosquitoes were obtained from various locations in Xinjiang, People's Republic of China. We analyzed the complete coding sequence of full-length small, medium, and large segments of these isolates. Molecular and phylogenetic analyses of the three complete TAHV genomes showed that sequence identity between isolates from China and Europe was more divergent, and an unexpected level of medium segment diversity was found among isolates from China compared with high levels of sequence conservation for the small and large segments. This study indicated that effects of genotypic diversity on the ecology, transmission, and pathogenicity of TAHV in China should be studied.
塔希纳病毒（TAHV）广泛分布于欧洲和亚洲。此前的研究报告称，从欧洲分离出的 TAHV 基因组具有高度保守性。在 2006 年和 007 年期间，从中国新疆的不同地区获得了三种来自蚊子的塔希纳病毒分离株。我们分析了这些分离株全长小、中、大片段的完整编码序列。对三个完整的 TAHV 基因组的分子和系统发育分析表明，与来自欧洲的分离株相比，来自中国的分离株之间的序列同一性更为离散，而且与小片段和大片段的高度序列保守性相比，中国分离株的中片段多样性水平出人意料。本研究表明，应该研究基因型多样性对中国 TAHV 的生态学、传播和致病性的影响。
