Aziz Shiekh Aejaz, Laway Bashir Ahmad, Rangreze Imran, Lone Mohd Iqbal, Ahmad Syed Nisar
Department of Medical Oncology, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Kashmir, India.
Indian J Endocrinol Metab. 2011 Jul;15(3):220-3. doi: 10.4103/2230-8210.83414.
Primary adrenal Non-Hodgkin's lymphoma is rare. The symptoms of the disease and response to treatment are variable depending on the type of lymphoma, tumor size, and presence of adrenal insufficiency. We report two cases of primary adrenal lymphoma who had varied presentations. One presenting with abdominal pain and weight loss was documented to have unilateral disease without any adrenal insufficiency and showed a good response to combination chemotherapy, while the second one had bilateral adrenal involvement with adrenal insufficiency and died after second chemotherapy. Functional adrenal involvement in lymphoma depends on the extent of involvement; patients with bilateral involvement almost always have adrenal insufficiency.
原发性肾上腺非霍奇金淋巴瘤较为罕见。该疾病的症状及对治疗的反应因淋巴瘤类型、肿瘤大小以及肾上腺功能不全的存在与否而有所不同。我们报告了两例表现各异的原发性肾上腺淋巴瘤病例。其中一例表现为腹痛和体重减轻，经诊断为单侧病变且无肾上腺功能不全，对联合化疗反应良好；而另一例双侧肾上腺均受累且伴有肾上腺功能不全，在第二次化疗后死亡。淋巴瘤累及肾上腺的功能情况取决于受累程度；双侧受累的患者几乎总会出现肾上腺功能不全。
