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双侧原发性肾上腺非霍奇金淋巴瘤且无肾上腺功能不全

Bilateral primary adrenal non-Hodgkin's lymphoma without adrenal insufficiency.

作者信息

Simpson William Greg, Babbar Paurush, Payne Lynnetta Faith

机构信息

West Virginia School of Osteopathic Medicine, Lewisburg, WV 24901, USA.

Cleveland Clinic Foundation, Glickman Urological and Kidney Institute, Cleveland, OH 44195, USA.

出版信息

Urol Ann. 2015 Apr-Jun;7(2):259-61. doi: 10.4103/0974-7796.152942.

Abstract

We are presenting a rare case of bilateral adrenal non-Hodgkin's lymphoma (NHL) that presented as a primary malignancy. An 83-year-old man presented with newly discovered bilateral adrenal incidentalomas, fatigue, and 30 pound weight loss. Of the 116 cases of primary adrenal NHL reported, over half have presented bilaterally and occur with adrenal insufficiency. Therefore, the finding of bilateral adrenal masses requires an urgent work-up of the functional status of the adrenal gland as well as a thorough analysis of the imaging characteristics seen on noncontrast computed tomography (CT) in order to maximize patient survival. Adrenal function testing was normal. Repeat CT imaging revealed rapidly growing lesions with high attenuations; both masses >10 HU. Histological examination of core biopsies discovered malignant lymphoma with no known past history of lymphoma. Our case coincides with the literature, which states that a mass with attenuation >10 HU in the adrenal glands has a high risk of malignancy.

摘要

我们报告一例罕见的双侧肾上腺非霍奇金淋巴瘤(NHL),其表现为原发性恶性肿瘤。一名83岁男性因新发现的双侧肾上腺偶发瘤、疲劳和体重减轻30磅就诊。在已报道的116例原发性肾上腺NHL病例中,超过一半为双侧发病,且伴有肾上腺功能不全。因此,发现双侧肾上腺肿块需要紧急检查肾上腺的功能状态,并对非增强计算机断层扫描(CT)所见的影像特征进行全面分析,以最大限度提高患者生存率。肾上腺功能测试正常。重复CT成像显示病变迅速增大,密度增高;两个肿块均>10 HU。核心活检的组织学检查发现为恶性淋巴瘤,患者既往无淋巴瘤病史。我们的病例与文献报道相符,文献指出肾上腺中密度>10 HU的肿块具有较高的恶性风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b07/4374272/cb92dc8a6964/UA-7-259-g001.jpg

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