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雷诺氏综合征与腕管综合征的相关性:荟萃分析。

The association of Raynaud's syndrome with carpal tunnel syndrome: a meta-analysis.

机构信息

Charité University Hospital, Berlin, Germany.

出版信息

Rheumatol Int. 2012 Mar;32(3):569-74. doi: 10.1007/s00296-011-2122-5. Epub 2011 Sep 7.

Abstract

Carpal tunnel syndrome (CTS) has traditionally been included among the diseases associated with Raynaud's syndrome (RS). The prevalence of RS in patients suffering from CTS is not well defined. The objective of this paper was to assess the prevalence of RS in patients with CTS-a meta-analysis of published data was performed. The PubMed database of the National Library of Medicine and ISI Web of Knowledge was used for studies dealing with RS and CTS. The studies provided sufficient data to estimate the prevalence of RS in patients of CTS. A forest plot was determined by the revealed prevalence. Statistical analysis was based on methods for a random effects meta-analysis and a finite mixture model for proportions. Publication bias was investigated with the linear regression test (Egger's method). A meta-regression was conducted by the year of publication. Eight eligible studies, contributing data on 675 subjects, were included in this meta-analysis. For CTS, a pooled prevalence of 15.5% and 95% CI (95% CI 0.043, 0.318) were obtained. Statistically publication bias was present (P value 0.143). A mixture model analysis found five latent classes. The meta-regression indicated that the estimated prevalence increased when the year of commencement increased, too. Within the decade (1957-1967), the odds ratio increased from 1 (95% CI 1.065, 1.112) to 2.340 (95% CI 1.886, 2.903). Despite some heterogeneity, there is a possible indication of an association between RS and patients with CTS.

摘要

腕管综合征(CTS)传统上被认为是与雷诺综合征(RS)相关的疾病之一。患有 CTS 的患者中 RS 的患病率尚未明确。本文旨在评估 CTS 患者中 RS 的患病率,并对已发表的数据进行荟萃分析。使用美国国立医学图书馆的 PubMed 数据库和 ISI Web of Knowledge 数据库检索有关 RS 和 CTS 的研究。这些研究提供了足够的数据来估计 CTS 患者中 RS 的患病率。通过显示的患病率确定森林图。统计分析基于随机效应荟萃分析和比例的有限混合模型方法。使用线性回归检验(Egger 法)评估发表偏倚。通过发表年份进行荟萃回归分析。这项荟萃分析纳入了 8 项符合条件的研究,共涉及 675 名受试者。对于 CTS,合并患病率为 15.5%(95%CI 0.043,0.318)。统计学上存在发表偏倚(P 值为 0.143)。混合模型分析发现了 5 个潜在类别。荟萃回归分析表明,当开始年份增加时,估计的患病率也会增加。在这十年间(1957-1967 年),比值比从 1(95%CI 1.065,1.112)增加到 2.340(95%CI 1.886,2.903)。尽管存在一定的异质性,但 RS 与 CTS 患者之间可能存在关联的迹象。

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