Mohokum M, Hartmann P, Schlattmann P
Department of Biometry and Clinical Epidemiology, Charité Universitätsmedizin Berlin, Berlin, Germany.
Int Angiol. 2012 Oct;31(5):408-13.
Vasospastic disorders of the digital circulation such as the Raynaud's syndrome (RS) are known side-effects of treatment of interferons. The prevalence of RS in patients during treatment with interferons agents is not well-defined. The objective of this paper was to assess the prevalence of RS in patients receiving interferons - a meta-analysis of published data was performed.
The PubMed database of the National Library of Medicine and ISI Web of Knowledge was used for studies dealing with RS and patients receiving interferons. The studies provided sufficient data to estimate the prevalence of RS in patients receiving interferons. A forest plot was determined by the revealed prevalences. Statistical analysis was based on methods for a random effects meta-analysis and a finite mixture model for proportions. Publication bias was investigated with the linear regression test (Egger's method). A meta-regression was conducted by the year of publication.
Six eligible studies, contributing data on 183 subjects, were included in this meta-analysis. For RS in patients receiving interferons a pooled prevalence of 13.6% and 95% CI (95% CI 0.026, 0.313) was obtained. A mixture model analysis found three latent classes. Statistically, publication bias was not present (p-value 0.335).
Despite some heterogeneity there is a possible indication of an association between RS and patients receiving interferons.
指循环系统的血管痉挛性疾病，如雷诺氏综合征（RS），是干扰素治疗已知的副作用。干扰素治疗期间患者中RS的患病率尚不明确。本文的目的是评估接受干扰素治疗的患者中RS的患病率——对已发表的数据进行荟萃分析。
使用美国国立医学图书馆的PubMed数据库和ISI Web of Knowledge来检索关于RS以及接受干扰素治疗患者的研究。这些研究提供了足够的数据来估计接受干扰素治疗患者中RS的患病率。通过所揭示的患病率确定森林图。统计分析基于随机效应荟萃分析方法和比例的有限混合模型。采用线性回归检验（Egger法）研究发表偏倚。按发表年份进行荟萃回归分析。
本荟萃分析纳入了6项符合条件的研究，共提供了183名受试者的数据。接受干扰素治疗患者中RS的合并患病率为13.6%，95%置信区间为（95%CI 0.026，0.313）。混合模型分析发现了三个潜在类别。在统计学上，不存在发表偏倚（p值为0.335）。
尽管存在一些异质性，但仍有可能表明RS与接受干扰素治疗的患者之间存在关联。
