[济南汉族人群5个Y-SNP位点的多态性分析]
[Polymorphic analysis of 5 Y-SNP loci in Han population of Jinan].
作者信息
Han Shu-Yi, Gao Hong-Mei, Zhang Mao-Xiu, Zheng Yan, Jia Yan-Fei, Ding Bu-Tong, Wang Yun-Shan
机构信息
Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, China.
出版信息
Fa Yi Xue Za Zhi. 2011 Jun;27(3):205-7, 210.
OBJECTIVE
To investigate polymorphism distribution of the 5 Y-SNP loci in Jinan Han population, and evaluate their potential in forensic application.
METHODS
Genotyping of 5 Y-SNP loci (M89, M9, M122, M134, M95) were executed in the sample of 103 unrelated Chinese male individuals in Jinan Han population by using fragment length discrepant allele specific PCR (FLDAS-PCR).
RESULTS
In 5 Y-SNP loci, genetic polymorphism were identified in Jinan Han population, and the ranges of gene diversity(GD) were 0.093 3-0.491 2. Twenty different haplotypes were observed and the haplotypes diversity (HD) was 0.867 9. Six different haplogroups were detected according to international association of Y chromosome nomenclature.
CONCLUSION
Five Y-SNP loci and their haplogroups in Jinan Han population are highly polymorphic, which can provide more information for the genetic structure analysis and forensic genetics research in the region.
目的
研究济南汉族人群5个Y染色体单核苷酸多态性（Y-SNP）位点的多态性分布情况，并评估其在法医学应用中的潜力。
方法
采用片段长度差异等位基因特异性PCR（FLDAS-PCR）技术，对济南汉族人群103名无血缘关系的男性个体样本进行5个Y-SNP位点（M89、M9、M122、M134、M95）的基因分型。
结果
在5个Y-SNP位点中，济南汉族人群存在基因多态性，基因多样性（GD）范围为0.093 3 - 0.491 2。观察到20种不同的单倍型，单倍型多样性（HD）为0.867 9。根据国际Y染色体命名协会，检测到6种不同的单倍群。
结论
济南汉族人群的5个Y-SNP位点及其单倍群具有高度多态性，可为该地区的遗传结构分析和法医学遗传学研究提供更多信息。
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