Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, USA.
Syst Biol Reprod Med. 2011 Oct;57(5):222-7. doi: 10.3109/19396368.2011.604819. Epub 2011 Sep 7.
The individual research group or independent investigator often requires access to samples from a unique well characterized subject population. Cohorts of such samples from a well-defined comparative population are rare and limited access can impede progress. This bottleneck can be removed by accessing the samples provided by biorepositories such as the NIH/NICHD Cooperative Reproductive Medicine Network (RMN) Biorepository (detailed in the preceeding manuscript in this issue. In those cases where the individual research group or independent investigator already has access to a unique population, comparisons between well-defined groups are often sought to contextualize the data. In both cases seamless integration of data resources associated with the samples is required to ensure optimal comparisons. At the most basic level this requires standardization of sample collection and storage, as well as a de-identified data base containing demographic, clinical, and laboratory values. To facilitate such interoperability, the reagents and protocols that have been adopted by the RMN Biorepository for the collection and storage of serum, blood, saliva and sperm are described.
个体研究小组或独立研究员通常需要访问来自具有独特特征的个体的样本。这种来自明确界定的比较人群的样本队列很少，而且有限的获取途径可能会阻碍研究进展。通过访问生物库（如 NIH/NICHD 合作生殖医学网络（RMN）生物库）提供的样本可以消除这一瓶颈（详细信息见本期中之前的一篇论文）。在个体研究小组或独立研究员已经可以访问独特人群的情况下，通常会寻求对明确界定的组进行比较，以便对数据进行背景分析。在这两种情况下，都需要对与样本相关的数据资源进行无缝集成，以确保最佳的比较。在最基本的层面上，这需要标准化样本的收集和存储，以及包含人口统计学、临床和实验室值的去识别数据库。为了促进这种互操作性，描述了 RMN 生物库为收集和存储血清、血液、唾液和精子而采用的试剂和方案。
