Detection of an influenza B virus strain with reduced susceptibility to neuraminidase inhibitor drugs.
作者信息
Bastien Nathalie, Gubbay Jonathan B, Richardson David, Sleeman Katrina, Gubareva Larisa, Li Yan
出版信息
J Clin Microbiol. 2011 Nov;49(11):4020-1. doi: 10.1128/JCM.05069-11. Epub 2011 Sep 7.
Abstract
摘要
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Surveillance for neuraminidase inhibitor resistance among human influenza A and B viruses circulating worldwide from 2004 to 2008.2004年至2008年全球流行的甲型和乙型人流感病毒中神经氨酸酶抑制剂耐药性监测
Antimicrob Agents Chemother. 2008 Sep;52(9):3284-92. doi: 10.1128/AAC.00555-08. Epub 2008 Jul 14.
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Influenza virus neuraminidase inhibitors.流感病毒神经氨酸酶抑制剂
Lancet. 2000 Mar 4;355(9206):827-35. doi: 10.1016/S0140-6736(99)11433-8.
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A single sequence change destabilizes the influenza virus neuraminidase tetramer.单个序列变化会使流感病毒神经氨酸酶四聚体不稳定。
Virology. 1997 Sep 15;236(1):66-75. doi: 10.1006/viro.1997.8709.
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Catalytic and framework mutations in the neuraminidase active site of influenza viruses that are resistant to 4-guanidino-Neu5Ac2en.对4-胍基-Neu5Ac2en具有抗性的流感病毒神经氨酸酶活性位点的催化和结构框架突变。
J Virol. 1997 May;71(5):3385-90. doi: 10.1128/JVI.71.5.3385-3390.1997.
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Mutation in the influenza virus neuraminidase gene resulting in decreased sensitivity to the neuraminidase inhibitor 4-guanidino-Neu5Ac2en leads to instability of the enzyme.流感病毒神经氨酸酶基因中的突变导致对神经氨酸酶抑制剂4-胍基-Neu5Ac2en的敏感性降低，进而导致该酶不稳定。
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