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Regulatory role of triiodothyronine in the degradation of low density lipoprotein by cultured human skin fibroblasts.

作者信息

Chait A, Bierman E L, Albers J J

出版信息

J Clin Endocrinol Metab. 1979 May;48(5):887-9. doi: 10.1210/jcem-48-5-887.

DOI:10.1210/jcem-48-5-887
PMID:219014
Abstract

Degradation of [125I]-labeled low density lipoprotein (LDL) by cultured normal human skin fibroblasts was enhanced by exposure to concentrations of L-triiodothyronine (T3) spanning the physiological range. Analysis of LDL concentration curves suggests that T3 may increase LDL receptor number rather than alter the affinity of LDL for its receptor. No effect of T3 on LDL degradation was observed in receptor negative cells. Thus thyroid hormone appears to regulate receptor-mediated LDL degradation by increasing the binding of the lipoprotein to its cell-surface receptor.

摘要

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