National Elites Foundation of Iran, Tehran, Iran.
Biol Trace Elem Res. 2012 Mar;145(3):369-74. doi: 10.1007/s12011-011-9194-7. Epub 2011 Sep 7.
In the present study, the protective effect of curcumin against sodium fluoride-induced nephrotoxicity was evaluated in rats. Renal injury was induced by daily administration of 600 ppm sodium fluoride in drinking water for 1 week. One week before the administration of fluoride, the animals selected as study group were given curcumin (10 and 20 mg/kg body weight, intraperitoneally). After 1 week, lipid peroxidation level, activities of superoxide dismutase, catalase, and level of glutathione in kidney homogenate were measured. Blood serum samples were examined for creatinine, serum urea, and blood urea nitrogen levels. Another group of rats received vitamin C (10 mg/kg) as standard antioxidant. The results show that curcumin and vitamin C treatment prior to fluoride administration normalized the levels of serum creatinine, serum urea, and blood urea nitrogen. Moreover, curcumin and vitamin C administrations prevented the antioxidant enzyme decreasing and lipid peroxidation levels imbalance. In conclusion, curcumin treatment at the doses of 10 and 20 mg/kg (intraperitoneally) showed significant nephroprotective effects.
在本研究中，评估了姜黄素对大鼠氟化钠诱导的肾毒性的保护作用。通过在饮用水中每天给予 600 ppm 氟化钠来诱导肾损伤 1 周。在给予氟化物前 1 周，将作为研究组的动物给予姜黄素（10 和 20 mg/kg 体重，腹腔内注射）。1 周后，测量肾脏匀浆中脂质过氧化水平、超氧化物歧化酶、过氧化氢酶的活性和谷胱甘肽水平。检查血清样本中的肌酐、血清尿素和血尿素氮水平。另一组大鼠给予维生素 C（10 mg/kg）作为标准抗氧化剂。结果表明，在给予氟化物之前给予姜黄素和维生素 C 处理可使血清肌酐、血清尿素和血尿素氮水平正常化。此外，姜黄素和维生素 C 的给药可防止抗氧化酶减少和脂质过氧化水平失衡。总之，姜黄素以 10 和 20 mg/kg（腹腔内）的剂量给药显示出显著的肾脏保护作用。
