Castaigne S, Chomienne C, Daniel M T, Berger R, Miclea J M, Ballerini P, Degos L
Department of Hematology M3, Hôpital Saint-Louis, Paris, France.
Nouv Rev Fr Hematol (1978). 1990;32(1):36-8.
Retinoic acid, the active metabolite of vitamin A has been shown to differentiate in vitro human leukaemic cells from patients with acute promyeolocytic leukaemia (APL). The results obtained in vivo with the 13-cis isomer of retinoic acid in combination with or after chemotherapy in four cases of APL are described. More recently Huang et al from the Shangai Institute of Haematology have treated 24 cases of APL with all-trans retinoic acid alone. They obtained 24 complete remissions. This success prompted us to treat patients with APL and a contra-indication to chemotherapy with all-trans retinoic acid. The results confirm the great efficacy of all-trans retinoic acid in APL.
视黄酸是维生素A的活性代谢产物，已被证明可在体外使急性早幼粒细胞白血病（APL）患者的人白血病细胞发生分化。本文描述了在4例APL患者中，13 - 顺式视黄酸与化疗联合使用或化疗后使用视黄酸的体内实验结果。最近，上海血液学研究所的黄等人单用全反式视黄酸治疗了24例APL患者。他们获得了24例完全缓解。这一成功促使我们用全反式视黄酸治疗有化疗禁忌证的APL患者。结果证实了全反式视黄酸在APL中的显著疗效。
