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散发性神经退行性疾病中线粒体 DNA 相关的线粒体功能障碍的作用和治疗。

Role and treatment of mitochondrial DNA-related mitochondrial dysfunction in sporadic neurodegenerative diseases.

机构信息

Department of Neurology, University of Kansas School of Medicine, Kansas City, 66160, USA.

出版信息

Curr Pharm Des. 2011;17(31):3356-73. doi: 10.2174/138161211798072535.

DOI:10.2174/138161211798072535
PMID:21902672
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3351798/
Abstract

Several sporadic neurodegenerative diseases display phenomena that directly or indirectly relate to mitochondrial function. Data suggesting altered mitochondrial function in these diseases could arise from mitochondrial DNA (mtDNA) are reviewed. Approaches for manipulating mitochondrial function and minimizing the downstream consequences of mitochondrial dysfunction are discussed.

摘要

几种散发性神经退行性疾病表现出与线粒体功能直接或间接相关的现象。本文回顾了提示这些疾病中线粒体功能改变的数据，这些数据可能源于线粒体 DNA（mtDNA）。讨论了操纵线粒体功能和最小化线粒体功能障碍下游后果的方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3003/3351798/94f63d22b134/nihms374585f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3003/3351798/64c7a89fab88/nihms374585f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3003/3351798/80c1efca177b/nihms374585f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3003/3351798/c0f35373d250/nihms374585f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3003/3351798/bc0f1f3ed49d/nihms374585f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3003/3351798/94f63d22b134/nihms374585f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3003/3351798/64c7a89fab88/nihms374585f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3003/3351798/80c1efca177b/nihms374585f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3003/3351798/c0f35373d250/nihms374585f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3003/3351798/bc0f1f3ed49d/nihms374585f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3003/3351798/94f63d22b134/nihms374585f5.jpg

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