维持胚胎干细胞多能性的 Wnt 信号通路。
Maintaining embryonic stem cell pluripotency with Wnt signaling.
机构信息
Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA.
出版信息
Development. 2011 Oct;138(20):4341-50. doi: 10.1242/dev.066209. Epub 2011 Sep 8.
Abstract
Wnt signaling pathways control lineage specification in vertebrate embryos and regulate pluripotency in embryonic stem (ES) cells, but how the balance between progenitor self-renewal and differentiation is achieved during axis specification and tissue patterning remains highly controversial. The context- and stage-specific effects of the different Wnt pathways produce complex and sometimes opposite outcomes that help to generate embryonic cell diversity. Although the results of recent studies of the Wnt/β-catenin pathway in ES cells appear to be surprising and controversial, they converge on the same conserved mechanism that leads to the inactivation of TCF3-mediated repression.
摘要
Wnt 信号通路控制脊椎动物胚胎中的谱系特化，并调节胚胎干细胞（ES 细胞）中的多能性，但在轴突特化和组织模式形成过程中，祖细胞自我更新和分化之间的平衡是如何实现的，这仍然存在很大争议。不同 Wnt 途径的上下文和阶段特异性效应产生了复杂且有时相反的结果，有助于产生胚胎细胞多样性。尽管最近对 ES 细胞中 Wnt/β-连环蛋白通路的研究结果似乎令人惊讶且存在争议，但它们都集中在相同的保守机制上，该机制导致 TCF3 介导的抑制失活。
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