Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA.
Development. 2011 Oct;138(20):4341-50. doi: 10.1242/dev.066209. Epub 2011 Sep 8.
Wnt signaling pathways control lineage specification in vertebrate embryos and regulate pluripotency in embryonic stem (ES) cells, but how the balance between progenitor self-renewal and differentiation is achieved during axis specification and tissue patterning remains highly controversial. The context- and stage-specific effects of the different Wnt pathways produce complex and sometimes opposite outcomes that help to generate embryonic cell diversity. Although the results of recent studies of the Wnt/β-catenin pathway in ES cells appear to be surprising and controversial, they converge on the same conserved mechanism that leads to the inactivation of TCF3-mediated repression.
Wnt 信号通路控制脊椎动物胚胎中的谱系特化，并调节胚胎干细胞（ES 细胞）中的多能性，但在轴突特化和组织模式形成过程中，祖细胞自我更新和分化之间的平衡是如何实现的，这仍然存在很大争议。不同 Wnt 途径的上下文和阶段特异性效应产生了复杂且有时相反的结果，有助于产生胚胎细胞多样性。尽管最近对 ES 细胞中 Wnt/β-连环蛋白通路的研究结果似乎令人惊讶且存在争议，但它们都集中在相同的保守机制上，该机制导致 TCF3 介导的抑制失活。
