Ultrasound and Elasticity Imaging Laboratory, Columbia University, New York, NY, USA.
Physiol Meas. 2011 Oct;32(10):1653-62. doi: 10.1088/0967-3334/32/10/012. Epub 2011 Sep 9.
Central blood pressure (CBP) has been established as a relevant indicator of cardiovascular disease. Despite its significance, CBP remains particularly challenging to measure in standard clinical practice. The objective of this study is to introduce pulse wave-based ultrasound manometry (PWUM) as a simple-to-use, non-invasive ultrasound-based method for quantitative measurement of the central pulse pressure. Arterial wall displacements are estimated using radiofrequency ultrasound signals acquired at high frame rates and the pulse pressure waveform is estimated using both the distension waveform and the local pulse wave velocity. The method was tested on the abdominal aorta of 11 healthy subjects (age 35.7 ± 16 y.o.). PWUM pulse pressure measurements were compared to those obtained by radial applanation tonometry using a commercial system. The average intra-subject variability of the pulse pressure amplitude was found to be equal to 4.2 mmHg, demonstrating good reproducibility of the method. Excellent correlation was found between the waveforms obtained by PWUM and those obtained by tonometry in all subjects (0.94 < r < 0.98). A significant bias of 4.7 mmHg was found between PWUM and tonometry. PWUM is a highly translational method that can be easily integrated in clinical ultrasound imaging systems. It provides an estimate of the pulse pressure waveform at the imaged location, and may offer therefore the possibility to estimate the pulse pressure at different arterial sites. Future developments include the validation of the method against invasive estimates on patients, as well as its application to other large arteries.
中心血压（CBP）已被确立为心血管疾病的相关指标。尽管其意义重大，但 CBP 在标准临床实践中仍然特别难以测量。本研究的目的是介绍基于脉搏波的超声压力测量法（PWUM），这是一种简单易用、基于非侵入性超声的方法，用于定量测量中心脉搏压。使用高帧率获取的射频超声信号来估计动脉壁位移，并使用扩张波形和局部脉搏波速度来估计脉搏压力波形。该方法在 11 名健康受试者（年龄 35.7 ± 16 岁）的腹主动脉上进行了测试。将 PWUM 脉搏压力测量值与使用商业系统的桡动脉平板测压法获得的测量值进行了比较。结果发现，脉搏压力幅度的个体内可变性平均为 4.2mmHg，表明该方法具有良好的可重复性。在所有受试者中，PWUM 获得的波形与平板测压法获得的波形之间均存在极好的相关性（0.94 < r < 0.98）。PWUM 与平板测压法之间存在 4.7mmHg 的显著偏差。PWUM 是一种高度转化的方法，可以很容易地集成到临床超声成像系统中。它提供了在成像位置处的脉搏压力波形的估计值，因此可能提供在不同动脉位置估计脉搏压力的可能性。未来的发展包括该方法在患者中与有创估计值的验证，以及将其应用于其他大动脉。
