Pole of Pharmacology and Therapeutics, Institute of Experimental and Clinical Research, University of Louvain Medical School Brussels, Belgium.
Front Pharmacol. 2011 Aug 25;2:49. doi: 10.3389/fphar.2011.00049. eCollection 2011.
to produce energy with limited resources and to fulfill the biosynthetic needs of proliferating cells. Both equations are solved when glycolysis is uncoupled from oxidative phosphorylation in the tricarboxylic acid cycle, a process known as the glycolytic switch. This review addresses in a comprehensive manner the main molecular events accounting for high-rate glycolysis in cancer. It starts from modulation of the Pasteur Effect allowing short-term adaptation to hypoxia, highlights the key role exerted by the hypoxia-inducible transcription factor HIF-1 in long-term adaptation to hypoxia, and summarizes the current knowledge concerning the necessary involvement of aerobic glycolysis (the Warburg effect) in cancer cell proliferation. Based on the many observations positioning glycolysis as a central player in malignancy, the most advanced anticancer treatments targeting tumor glycolysis are briefly reviewed.
癌症是一种代谢疾病，涉及两个代谢方程的解决：在有限的资源下产生能量和满足增殖细胞的生物合成需求。当糖酵解与三羧酸循环中的氧化磷酸化解偶联时，这两个方程都得到了解决，这个过程被称为糖酵解开关。这篇综述全面地阐述了导致癌症中高糖酵解的主要分子事件。它从调节巴斯德效应开始，允许短期适应缺氧，强调了缺氧诱导转录因子 HIF-1 在长期适应缺氧中的关键作用，并总结了目前关于有氧糖酵解（瓦博格效应）在癌细胞增殖中必需的知识。基于将糖酵解定位为恶性肿瘤核心因素的大量观察，本文简要回顾了针对肿瘤糖酵解的最先进的抗癌治疗方法。
