School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.
Evid Based Complement Alternat Med. 2012;2012:818230. doi: 10.1155/2012/818230. Epub 2011 Aug 22.
Urtica atrichocaulis, an endemic plant to China, is commonly used to treat rheumatoid arthritis even though its pharmaceutical activities and chemical constituents were not studied. Herein, we reported our investigations on the chemical compositions of the phenolic compounds-rich fraction from U. atrichocaulis (TFUA) and their antirheumatoid arthritis activities. We found that the TFUA significantly inhibited the adjuvant-induced rats arthritis, carrageenin-induced rats paw edema, cotton pellet-induced mice granuloma, and the acetic acid-induced mice writhing response. Our phytochemical investigations on the TFUA resulted in the first-time isolation and identification of 17 phenolic constituents and a bis (5-formylfurfuryl) ether. The extensive HPLC analysis also revealed the chemical compositions of TFUA. Our further biological evaluation of the main phenolic components, individually and collectively, indicated that the antirheumatoid arthritis activities of TFUA were the combined effect of multiple phenolic constituents.
荨麻科植物大荨麻，是中国特有的植物，通常用于治疗类风湿性关节炎，尽管其药用活性和化学成分尚未得到研究。在此，我们报道了对荨麻科植物富酚部位（TFUA）的化学成分及其抗类风湿关节炎活性的研究。我们发现 TFUA 能显著抑制佐剂诱导的大鼠关节炎、角叉菜胶诱导的大鼠足肿胀、棉酚诱导的小鼠肉芽肿和醋酸诱导的小鼠扭体反应。我们对 TFUA 的植物化学研究首次分离鉴定了 17 种酚类成分和一种双（5-甲酰基糠基）醚。广泛的 HPLC 分析还揭示了 TFUA 的化学成分。我们对主要酚类成分的进一步生物评价表明，TFUA 的抗类风湿关节炎活性是多种酚类成分的综合作用。
