膀胱内透明质酸和硫酸软骨素对膀胱疼痛综合征/间质性膀胱炎的影响。
Impact of intravesical hyaluronic acid and chondroitin sulfate on bladder pain syndrome/interstitial cystitis.
作者信息
Porru Daniele, Leva Fabio, Parmigiani Alberto, Barletta Davide, Choussos Dimitrios, Gardella Barbara, Daccò Maria Diletta, Nappi Rossella Elena, Allegri Massimo, Tinelli Carmine, Bianchi Carlo Maria, Spinillo Arsenio, Rovereto Bruno
机构信息
Urology Department, IRCCS Policlinico San Matteo, Pavia, Italy.
出版信息
Int Urogynecol J. 2012 Sep;23(9):1193-9. doi: 10.1007/s00192-011-1546-5. Epub 2011 Sep 9.
INTRODUCTION AND HYPOTHESIS
Intravesical instillations of hyaluronic acid (HA) and chondroitin sulfate (CS) may lead to regeneration of the damaged glycosaminoglycan layer in interstitial cystitis/bladder pain syndrome (IC/BPS).
METHODS
Twenty-two patients with IC/BPS received intravesical instillations (40 ml) of sodium HA 1.6% and CS 2.0% in 0.9% saline solution (IALURIL, IBSA) once weekly for 8 weeks, then once every 2 weeks for the next 6 months.
RESULTS
The score for urgency was reduced from 6.5 to 3.6 (p = 0.0001), with a reduction in pain scores from an average of 5.6 to 3.2 (p = 0.0001). The average urine volume increased from 129.7 to 162 ml (p < 0.0001), with a reduction in the number of voids in 24 h, from 14 to 11.6 (p < 0.0001). The IC Symptom and Problem Index decreased from 25.7 to 20.3 (p < 0.0001), and the Pain Urgency Frequency score, from 18.7 to 12.8 (p < 0.0001).
CONCLUSION
The treatment appeared to be effective and well tolerated in IC/BPS in this initial experience.
引言与假设
膀胱内灌注透明质酸（HA）和硫酸软骨素（CS）可能会促使间质性膀胱炎/膀胱疼痛综合征（IC/BPS）中受损的糖胺聚糖层再生。
方法
22例IC/BPS患者接受膀胱内灌注（40毫升）1.6%的HA钠和2.0%的CS于0.9%盐溶液中（IALURIL，IBSA），每周一次，共8周，接下来6个月每2周一次。
结果
尿急评分从6.5降至3.6（p = 0.0001），疼痛评分从平均5.6降至3.2（p = 0.0001）。平均尿量从129.7毫升增至162毫升（p < 0.0001），24小时排尿次数从14次减至11.6次（p < 0.0001）。IC症状与问题指数从25.7降至20.3（p < 0.0001），疼痛尿急频率评分从18.7降至12.8（p < 0.0001）。
结论
在这一初步经验中，该治疗方法在IC/BPS中似乎有效且耐受性良好。
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