Department of Preventive Medicine, School of Medicine, Institute for Medical Genetics, Keimyung University, 2800 Dalgubeoldaero, Dalseo-Gu, Daegu, Korea.
Inflamm Res. 2011 Dec;60(12):1099-105. doi: 10.1007/s00011-011-0372-z. Epub 2011 Sep 9.
Obesity is characterized by the activation of an inflammatory process leading to an increase in proinflammatory cytokines and adipokines. This study was designed to investigate the genetic association between tumor necrosis factor-α (TNF-α) polymorphisms and the risk of obesity in the Korean population.
Three single nucleotide polymorphisms [G-238A (rs361525), C-857T (rs1799724), and C-863A (rs1800630)] in the promoter region of TNF-α gene were analyzed in 123 control [body mass index (BMI) between 18 and 23] and 208 overweight/obese (BMI ≥ 23) subjects.
The mean values of BMI in the control and overweight/obese groups were 21.1 ± 1.4 and 25.4 ± 1.8, respectively. Of the three SNPs, G-238A presented a significant association with overweight/obesity in the codominant model; the frequency of the G/G genotype in the overweight/obese group was 9.3% higher than that in the control group (P = 0.0046). When control and overweight/obesity subjects were combined together and analyzed, the level of high-density lipoprotein (HDL) was significantly higher in the C-857T C/C type SNP (P < 0.05).
The results of this study suggest that the G allele of G-238A in TNF-α gene may be a risk factor for overweight/obesity in the Korean population and that the C allele of C-857T may be an protective factor in relation to the HDL level in the general Korean population.
肥胖的特征是炎症过程的激活，导致促炎细胞因子和脂肪因子的增加。本研究旨在探讨肿瘤坏死因子-α（TNF-α）基因多态性与韩国人群肥胖风险的遗传相关性。
分析了 TNF-α基因启动子区域的三个单核苷酸多态性[G-238A（rs361525）、C-857T（rs1799724）和 C-863A（rs1800630）]在 123 名对照（BMI 在 18-23 之间）和 208 名超重/肥胖（BMI≥23）受试者中的情况。
对照组和超重/肥胖组的 BMI 平均值分别为 21.1±1.4 和 25.4±1.8。在这三个 SNP 中，G-238A 在共显性模型中与超重/肥胖显著相关；超重/肥胖组的 G/G 基因型频率比对照组高 9.3%（P=0.0046）。当将对照组和超重/肥胖组合并分析时，C-857T C/C 型 SNP 的高密度脂蛋白（HDL）水平显著升高（P<0.05）。
本研究结果表明，TNF-α 基因 G-238A 中的 G 等位基因可能是韩国人群超重/肥胖的危险因素，而 C-857T 的 C 等位基因可能是与普通韩国人群 HDL 水平相关的保护因素。
