Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria 3050, Australia.
Protein Cell. 2011 Aug;2(8):620-30. doi: 10.1007/s13238-011-1088-0. Epub 2011 Sep 9.
The pathways leading to the development of different dendritic cell (DC) subsets have long been unclear. In recent years, a number of precursors on the route to DC development, both under steady state and inflammatory conditions, have been described, and the nature of these pathways is becoming clearer. In addition, the development of various knockout mouse models and an in vitro system modelling DC development have revealed the role of numerous cytokines and transcription factors that influence DC development. Here, we review recent findings on the factors important in DC development in the context of the developmental pathways that have been described.
不同树突状细胞 (DC) 亚群的发展途径长期以来一直不明确。近年来,在稳态和炎症条件下,已经描述了通向 DC 发育的许多前体,这些途径的性质变得更加清晰。此外,各种基因敲除小鼠模型和体外系统模拟 DC 发育的发展揭示了影响 DC 发育的众多细胞因子和转录因子的作用。在这里,我们回顾了在已描述的发育途径背景下,对 DC 发育重要因素的最新发现。