miRNAs 对单核细胞来源的树突状细胞的功能调控
Functional regulation of monocyte-derived dendritic cells by microRNAs.
机构信息
The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.
出版信息
Protein Cell. 2012 Jul;3(7):497-507. doi: 10.1007/s13238-012-0042-0. Epub 2012 Jul 10.
Abstract
Dendritic cells (DCs) as a rare type of leukocytes play an important role in bridging the innate and adaptive immune system. A subset of DCs, monocyte-derived dendritic cells (moDCs), exists in very low numbers at steady state but become abundant in inflammatory states. These inflammation-associated DCs are potent producers of pro-inflammatory cytokines and potent inducers of T helper differentiation. They behave as a "double-edge" sword so that they not only mediate protective immunity but also immuno-pathology. It is still incompletely understood how their function is regulated. Emerging evidence indicates that microRNAs (miRNAs), as a new class of gene regulators, potently regulate the function of moDCs. Here we summarize recent progress in this area.
摘要
树突状细胞 (DCs) 作为一种罕见的白细胞类型，在连接先天免疫和适应性免疫系统方面发挥着重要作用。DCs 的一个亚群，单核细胞衍生的树突状细胞 (moDCs)，在稳态时数量非常少，但在炎症状态下变得丰富。这些与炎症相关的 DCs 是促炎细胞因子的有力产生者，也是 T 辅助细胞分化的有力诱导者。它们表现为一把“双刃剑”，既能介导保护性免疫，也能介导免疫病理学。它们的功能如何调节仍不完全清楚。新出现的证据表明，microRNAs（miRNAs）作为一类新的基因调节剂，能够强有力地调节 moDCs 的功能。在这里，我们总结了这一领域的最新进展。
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